Effect of Compound Jiaogulan Yizhi Granules for Improving Memory in Mice

DU Zheng-cai; DENG Jia-gang

doi:10.13422/j.cnki.syfjx.2012.15.073

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Effect of Compound Jiaogulan Yizhi Granules for Improving Memory in Mice

更新时间：2024-09-23

- Effect of Compound Jiaogulan Yizhi Granules for Improving Memory in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 250-253(2012)
- 作者机构：
  
  广西中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.073
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]杜正彩,邓家刚.复方绞股蓝益智颗粒改善记忆作用药效学研究[J].中国实验方剂学杂志,2012,18(15):250-253.

DU Zheng-cai, DENG Jia-gang. Effect of Compound Jiaogulan Yizhi Granules for Improving Memory in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 250-253.
[1]杜正彩,邓家刚.复方绞股蓝益智颗粒改善记忆作用药效学研究[J].中国实验方剂学杂志,2012,18(15):250-253. DOI： 10.13422/j.cnki.syfjx.2012.15.073.

DU Zheng-cai, DENG Jia-gang. Effect of Compound Jiaogulan Yizhi Granules for Improving Memory in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 250-253. DOI： 10.13422/j.cnki.syfjx.2012.15.073.

摘要

目的:观察复方绞股蓝益智颗粒（CJG）改善记忆的作用。方法:通过跳台试验、避暗实验及水迷宫试验

观察CJG 0.83

1.67

5.00 g·kg-1.d-1剂量组对小鼠改善记忆作用。结果:CJG中、高剂量组小鼠对避暗试验潜伏期有明显延长作用（P<0.05）

错误次数及进入暗室的动物数明显减少（P<0.01）;水迷宫试验CJG高剂量组小鼠到达终点的时间明显减少（P<0.05）

CJG低、中、高剂量组2 min内到终点的动物明显增加（P<0.05）。结论:CJG具有改善记忆的功能。

Abstract

Objective: To observe the effect of compound Jiaogulan Yizhi granules（CJG）for improving memory in mice.Method: Experiments of avoiding darkness

jumping stage and water-maze were conducted in mice.The effect of CJG with three doses（0.83

1.67

5.00 g·kg-1·d-1） on memory of mice was observed.Result: In the avoiding darkness test

compared with the control group

the latency time of CJG（medium and high doses） was significantly prolonged（P<0.05）

the error times and the number of entering the darkroom were significantly reduced（P<0.01）.In the water maze test

compared with control group

the swimming time in CJG high dose group was significantly reduced（P<0.05）

and the number of mice to reach the final destination within 2 min in CJG groups（low

medium and high doses） was significantly increased（P<0.05）.Conclusion: CJG has the effect of improving memory.

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Related Author

DENG Jia-gang

DU Zheng-cai

CAO Hui

WU Dongsheng

ZOU Bo

JIANG Shaijin

LIU Erle

XIA Yiling

Related Institution

The First Hospital of Hunan University of Chinese Medicine

School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine

Shanxi Provincial Key Laboratory of Chinese Medicine Encephalopathy & Higher Education Key Laboratory of Brain Science, Shanxi University of Chinese Medicine

Shandong University of Traditional Chinese Medicine

Institute of Materia Medica, Chinese Academy of Medical & Peking Union Medical College

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