Effect of Polygonum Sangdang on the Expression of ICAM-1 and NF-κB in Synovial Membrane of Rats with Acute Gouty Arthritis

WANG Ren-ai; WU Ping; YANG Yan; ZHANG Guang-mei; ZHAO Xie-hui

doi:10.13422/j.cnki.syfjx.2012.15.074

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Effect of Polygonum Sangdang on the Expression of ICAM-1 and NF-κB in Synovial Membrane of Rats with Acute Gouty Arthritis

更新时间：2024-09-23

- Effect of Polygonum Sangdang on the Expression of ICAM-1 and NF-κB in Synovial Membrane of Rats with Acute Gouty Arthritis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 257-259(2012)
- 作者机构：
  
  青海大学医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.074
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]王仁嫒,吴萍,杨艳,张广梅,赵协慧.桑当对痛风性关节炎大鼠滑膜组织ICAM-1与NF-κB表达的影响[J].中国实验方剂学杂志,2012,18(15):257-259.

WANG Ren-ai, WU Ping, YANG Yan, et al. Effect of Polygonum Sangdang on the Expression of ICAM-1 and NF-κB in Synovial Membrane of Rats with Acute Gouty Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 257-259.
[1]王仁嫒,吴萍,杨艳,张广梅,赵协慧.桑当对痛风性关节炎大鼠滑膜组织ICAM-1与NF-κB表达的影响[J].中国实验方剂学杂志,2012,18(15):257-259. DOI： 10.13422/j.cnki.syfjx.2012.15.074.

WANG Ren-ai, WU Ping, YANG Yan, et al. Effect of Polygonum Sangdang on the Expression of ICAM-1 and NF-κB in Synovial Membrane of Rats with Acute Gouty Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 257-259. DOI： 10.13422/j.cnki.syfjx.2012.15.074.

摘要

目的:研究桑当防治急性痛风性关节炎的作用机制。方法:采用尿酸钠结晶致急性痛风性关节炎大鼠模型

每日ig桑当（120

60 mg·kg-1）

秋水仙碱（0.28 mg·kg-1）

连用7 d后组织取材

制备标本

应用ELISA法测定滑膜组织中黏附分子1（ICAM-1）与核转录因子κB（NF-κB）的水平

观察桑当对ICAM-1与NF-κB表达的影响。结果:正常组、模型组、桑当低、高剂量组、秋水仙碱组ICAM-1分别为（142.83±22.30）

（376.00±20.99）

（292.67±24.78）

（202.50±27.03）

（179.17±28.19）μg·L-1;NF-κB分别为（856.67±50.84）

（3 023.83±121.73）

（2 685.33±189.85）

（1 684.25±206.62）

（1 566.17±206.05）ng·L-1。模型组ICAM-1

NF-κB水平较正常组明显增高（P<0.01）;桑当低、高剂量组均可显著降低二者的表达。结论:桑当能降低大鼠滑膜组织中ICAM-1与NF-κB的异常表达与激活

这可能是其防治痛风性关节炎的作用机制之一。

Abstract

Objective:To study Sangdown’s mechanism for prevention and treatment of acute gouty arthritis.Method: Sodium urate crystal was used to induce rat model of acute gouty arthritis.Rats were daily ig given Sangdown（120

60 mg·kg-1）

colchicine（0.28 mg·kg-1） for 7 days.Afterwards

tissue specimens were prepared.The level of synovial tissue adhesion molecule 1（ICAM-1） and nuclear factor kappa B（NF-kappa B） was measured by ELISA determination.Result: In the normal gnoup

model group

Sangdown low and high dose groups

colchicine group

ICAM-1 were（142.83±22.30）（376.00±20.99）（292.67±24.78）（202.50±27.03）（179.17±28.19） μg·L-1 respectively and NF-κB were（856.67±50.84）

（3 023.83±121.73）

（2 685.33±189.85）

（1 684.25±206.62） ng·L-1

（1 566.17±206.05）ng·L-1 respectively.ICAM-1

NF-κB in model group were significantly higher than those in the normal group（P<0.01）;Sangdown（low and high dose） could significantly reduce the expression of the two.Conclusion: Sandown can reduce ICAM-1 and NF-κB in synovial tissue in rats.This may be one of the mechanisms for prevention and treatment of gouty arthritis.

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Related Author

WANG Ren-ai

WU Ping

YANG Yan

ZHANG Guang-mei

ZHAO Xie-hui

DU Mingrui

SONG Zhe

LI Huayan

Related Institution

The First Clinical Medical College， Henan University of Chinese Medicine

The First Affiliated Hospital of Henan University of Chinese Medicine

Beijing Shijitan Hospital，Capital Medical University

Institute of Basic Theory for Chinese Medicine，China Academy of Chinese Medical Sciences

Henan Second Provincial People's Hospital

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