Effect of Traditional Chinese Herbs on Endothelial Nitric Oxide Synthase Transcriptional Regulation

GAN Wo-ting; SUN Li; HAN Xin; LING Shuang; XU Jin-wen

doi:10.13422/j.cnki.syfjx.2012.15.078

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Effect of Traditional Chinese Herbs on Endothelial Nitric Oxide Synthase Transcriptional Regulation

更新时间：2024-09-23

- Effect of Traditional Chinese Herbs on Endothelial Nitric Oxide Synthase Transcriptional Regulation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 323-327(2012)
- 作者机构：
  
  上海中医药大学穆拉德中药现代化研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.078
  CLC： R285.5
- Published：2012
- 稿件说明：
移动端阅览
[1]甘我挺,孙丽,韩欣,凌霜,许锦文.中药对内皮型一氧化氮合酶转录的调控作用[J].中国实验方剂学杂志,2012,18(15):323-327.

GAN Wo-ting, SUN Li, HAN Xin, et al. Effect of Traditional Chinese Herbs on Endothelial Nitric Oxide Synthase Transcriptional Regulation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 323-327.
[1]甘我挺,孙丽,韩欣,凌霜,许锦文.中药对内皮型一氧化氮合酶转录的调控作用[J].中国实验方剂学杂志,2012,18(15):323-327. DOI： 10.13422/j.cnki.syfjx.2012.15.078.

GAN Wo-ting, SUN Li, HAN Xin, et al. Effect of Traditional Chinese Herbs on Endothelial Nitric Oxide Synthase Transcriptional Regulation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 323-327. DOI： 10.13422/j.cnki.syfjx.2012.15.078.

摘要

对内皮型一氧化氮合酶（endothelial nitric oxide synthase

eNOS）转录调控相关文献整理和分析

着重介绍中药的心脑血管防治作用的药理机制。从PubMed数据库和中国知网数据库检索出相关文献

结合《中医药学高级丛书-中药药理学》、《中药现代研究与应用》和《最新中药药理与临床应用》中对相关中药的介绍分析文献。简述了eNOS基因转录调控的机制包括表观遗传调控、相关转录因子、27 nt小RNA负反馈调控、mRNA稳定性等;总结了能调控eNOS基因转录的中药成分和复方制剂及其药理作用机制。结合中药治疗慢性疾病的优势

提出从分子水平（如表观遗传特征的缓慢变化）研究中药防治心脑血管疾病的药理机制的方法。

Abstract

Based on endothelial nitric oxide synthase（eNOS） transcription regulation related literatures

this review introduced emphatically the pharmacological mechanism of the cardiovascular protection of traditional Chinese medicine.Combined with the knowledge of related Chinese herbs in ’the senior series of traditional Chinese medicine-Chinese medicine pharmacology’

’the modern research and application of Chinese medicine’ and ’the latest pharmacology and clinical applications of traditional Chinese medicine’

author analyzed the literatures from PubMed database and CNKI database.Briefly stated eNOS transcription regulation mechanism including epigenetic regulation

related transcription factors

27 nt small RNA negative feedback control

mRNA stability

etc;Summarized the traditional Chinese medicine compounds and monomers which can regulate eNOS gene transcription and their pharmacological mechanism.Combined with the advantages of Chinese traditional medicine for the treatment of chronic disease

the study of traditional Chinese medicine at molecular level（such as epigenetic regulation） should be taken up.

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Related Author

XU Jin-wen

LING Shuang

HAN Xin

SUN Li

GAN Wo-ting

LI Yujie

WANG Luqi

LIU Chengcheng

Related Institution

Artemisinin Research Center， China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Artemisinin Research Center, China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences

Henan Province Hospital of Traditional Chinese Medicine

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