Montelukast Combined with Shegan Mahuang Tang for Treating of 86 Patients with Cough Variant Asthma

WANG Hong-shan; LI Guo-hao; CAO Yi-min; LIN Mei-yi; DENG Li-li; GUAN Ai-ping

doi:10.13422/j.cnki.syfjx.2012.15.080

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Montelukast Combined with Shegan Mahuang Tang for Treating of 86 Patients with Cough Variant Asthma

更新时间：2024-09-23

- Montelukast Combined with Shegan Mahuang Tang for Treating of 86 Patients with Cough Variant Asthma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 273-275(2012)
- 作者机构：
  
  广州市第一人民医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.080
  CLC： R562.25
- Published：2012
- 稿件说明：
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[1]王红珊,李国豪,曹毅敏,林美仪,邓丽丽,关爱萍.射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘86例[J].中国实验方剂学杂志,2012,18(15):273-275.

WANG Hong-shan, LI Guo-hao, CAO Yi-min, et al. Montelukast Combined with Shegan Mahuang Tang for Treating of 86 Patients with Cough Variant Asthma[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 273-275.
[1]王红珊,李国豪,曹毅敏,林美仪,邓丽丽,关爱萍.射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘86例[J].中国实验方剂学杂志,2012,18(15):273-275. DOI： 10.13422/j.cnki.syfjx.2012.15.080.

WANG Hong-shan, LI Guo-hao, CAO Yi-min, et al. Montelukast Combined with Shegan Mahuang Tang for Treating of 86 Patients with Cough Variant Asthma[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 273-275. DOI： 10.13422/j.cnki.syfjx.2012.15.080.

摘要

目的:研究射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘的临床疗效。方法:172例咳嗽变异型哮喘患者随机分为两组

对照组给予硫酸沙丁胺醇气雾剂（1喷/次

3次/d）联合酮替芬（2 mg.d-1）治疗

治疗组给予射干麻黄汤联合孟鲁司特（10 mg.d-1）口服治疗

疗程均为2周

比较两组临床有效率

评定治疗前后患者的临床症状、肺功能变化。结果:两组患者的临床症状与治疗前比较有明显改善

治疗后治疗组与对照组分别为（1.1±0.2）

（1.8±0.3）分（P<0.05）;治疗组患者呼气峰流速昼夜变异率为5.1%

明显低于对照组（9.2%）（P<0.05）;治疗组患者临床总有效率91.9%

对照组82.6%

治疗组优于对照组（P<0.05）。结论:射干麻黄汤联合孟鲁司特治疗咳嗽变异型哮喘临床效果显著。

Abstract

Objective: To study the clinical effect of montelukast combined with Shegan Mahuang Tang in treatment of cough variant asthma（CVA）.Method:One hundred and seventy two patients with CVA were randomly divided into treatment group and control group

and the patients in control group were treated with salbutamol sulfate aerosol（1 dose per time

tid） combined with ketotifen（2 mg·d-1）

the patients in treatment group was received with montelukast（10 mg·d-1） combined with Shegan Mahuang Tang.In two groups the treatment lasted for two weeks.Forced expiratory volume 1（FEV1）

peak expiratory flow（PEF） and clinical symptom were measured

the clinical effect was compared.Result: The clinical symptom was changed by the teatments significantly.And the score in treatment group and control group was 1.1±0.2 and 1.8±0.3（P<0.05）;the PEF changes of treatment group was 5.1%

it was lower than 9.2% in the control’s（P<0.05）.The total effective rate of treatment group was 91.9%

and the rate of control group was 82.6%

（P<0.05）.Conclusion: Shegan Mahuang Tang combined with montelukast shows satisfactory clinical efficacy in CVA

and it is worthy of clinical use.

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Related Author

WANG Hong-shan

LI Guo-hao

CAO Yi-min

LIN Mei-yi

DENG Li-li

GUAN Ai-ping

HAN Yi

HAN Yubo

Related Institution

First Affiliated Hospital of Heilongjiang University of Chinese Medicine

Heilongjiang University of Chinese Medicine

Xiyuan Hospital of China Academy of Chinese Medical Sciences

Beijing University of Chinese Medicine

The Third Affiliated Hospital of Beijing University of Chinese Medicine

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