LI Xin, CAO Bao-li. Effect of Compound Rhizoma Curcumae Powder on Expression of VEGF in Ectopic and Eutopic Endometrium of Patients with Endometriosis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 293-296.
LI Xin, CAO Bao-li. Effect of Compound Rhizoma Curcumae Powder on Expression of VEGF in Ectopic and Eutopic Endometrium of Patients with Endometriosis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 293-296. DOI: 10.13422/j.cnki.syfjx.2012.15.084.
Effect of Compound Rhizoma Curcumae Powder on Expression of VEGF in Ectopic and Eutopic Endometrium of Patients with Endometriosis
Objective:To study the expression of vascular endothelial growth factor(VEGF) in ectopic and eutopic endometrium in patients with endometriosis and significance of the expression
and to study the effect of compound Rhizoma Curcumae powder on expression of VEGF in ectopic and eutopic endometrium in patients with endometriosis
the mechanism of compound Rhizoma Curcumae powder was explored in order to further clinical application.Method:Using immunohistochemistry SP method
the expression level of VEGF was detected in ectopic and eutopic endometrium in hospitalized patients with endometriosis
who had undertaken laparoscopic surgery in Department of Gynecology in Tianjin Nankai Hospital from July 2009 to January 2011
twenty-three cases were given compound Rhizoma Curcumae powder for 3 months before surgery(treatment group)and 30 cases without treatment entered endometriosis group
compared with that in endometrium from hysteromyoma patients of 30 cases(control group).Result:Expression of VEGF was significantly higher in eutopic endometrium of endometriosis group than that of control group(P<0.05).Expression of VEGF in ectopic endometrium was lower than that in eutopic endometrium(P<0.01) and was higher than that of control group(P<0.05).The expression of VEGF in ectopic endometrium and eutopic endometrium in patients of treatment group were significantly lower than that in endometriosis group(P<0.01).Conclusion:Significantly increased expression of VEGF in ectopic and eutopic endometrium in patients with endometriosis may be closely related to pathogenesis of endometriosis.Compound Rhizoma Curcumae powder may reduce the expression of VEGF in ectopic and eutopic endometrium in patients with endometriosis
thus it may play a therapeutic role in inhibiting angiogenesis in the endometrium.
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Related Author
LI Xin
CAO Bao-li
LI Wei-hong
LI Li
TAN Wen-ju
WAN Gui-ping
ZHANG Zhen-zhen
TANG Wei-wei
Related Institution
Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing Institute of Traditional Chinese Medicine, Beijing Evidence-based Chinese Medicine Center
Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Center for Evidence-based Chinese Medicine, Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences
College of Pharmacy,Gansu University of Chinese Medicine
Affiliated Hospital of Gansu University of Chinese Medicine