Clinical Observation of Infantile Cytomegalovirus Hepatitiswith Cholestasis Treated with Powder of Bear Gallbladder

LIU Yan-hong; YAN An-ping; JIA Mei-yun

doi:10.13422/j.cnki.syfjx.2012.15.085

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Clinical Observation of Infantile Cytomegalovirus Hepatitiswith Cholestasis Treated with Powder of Bear Gallbladder

更新时间：2024-09-23

- Clinical Observation of Infantile Cytomegalovirus Hepatitiswith Cholestasis Treated with Powder of Bear Gallbladder
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 15, Pages: 300-302(2012)
- 作者机构：
  
  郑州人民医院新生儿科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.15.085
  CLC： R725.7
- Published：2012
- 稿件说明：
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[1]刘艳红,闫安平,贾美云.熊胆粉联合西药治疗婴儿巨细胞病毒感染相关胆汁淤积性肝炎[J].中国实验方剂学杂志,2012,18(15):300-302.

LIU Yan-hong, YAN An-ping, JIA Mei-yun. Clinical Observation of Infantile Cytomegalovirus Hepatitiswith Cholestasis Treated with Powder of Bear Gallbladder[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 300-302.
[1]刘艳红,闫安平,贾美云.熊胆粉联合西药治疗婴儿巨细胞病毒感染相关胆汁淤积性肝炎[J].中国实验方剂学杂志,2012,18(15):300-302. DOI： 10.13422/j.cnki.syfjx.2012.15.085.

LIU Yan-hong, YAN An-ping, JIA Mei-yun. Clinical Observation of Infantile Cytomegalovirus Hepatitiswith Cholestasis Treated with Powder of Bear Gallbladder[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(15): 300-302. DOI： 10.13422/j.cnki.syfjx.2012.15.085.

摘要

目的:评价熊胆粉联合更昔洛韦治疗婴儿巨细胞病毒（CMV）感染相关胆汁淤积性肝炎的治疗效果。方法:将46例婴儿巨细胞病毒感染相关胆汁淤积性肝炎患儿随机分为治疗组24例与对照组22例。两组均给予更昔洛韦5 mg·kg-1

12 h/次等综合对症治疗。治疗组在此基础上加用熊胆粉0.02 g·kg-1口服

2次/d

均连用14 d

观察结果。结果:治疗组治疗前后比较血清总胆汁酸、血清总胆红素、直接胆红素、肝内胆管宽度差异有统计学意义（P<0.01）

对照组治疗前后直接胆红素、胆汁酸、肝内胆管宽度无统计学意义;两组黄疸开始消退时间、黄疸完全消退时间之间差异有非常显著性意义（P<0.01）。结论:熊胆粉可以降低总胆红素和直接胆红素

降低胆汁酸水平

减轻肝功能损伤

减轻胆管扩张

促进黄疸消退。

Abstract

Objective:To evaluate the therapeutic effects of powder of bear gallbladder combined with ganciclovir in infantile cytomegalovirus hepatitiswith cholestasis.Method:Rorty-six infantiles cytomegalovirus hepatitiswith cholestasis were randomly divided into tow groups: the treatment group（n=24）and the control group（n=22）.The treatment group received powder of bear gallbladder（0.02 g·kg-1） once day orally

ganciclovir was given in the two groups for two weeks.Result: There were significant differences in IBIL and TBA between the two groups after two weeks（P<0.01）.There were very significant differences in time of initial jaundice disappearance and complete disappearance after two weeks（P<0.01）.Conclusion:As external ademetionine

powder of bear gallbladder could supplement absent endogenous ademetionine

efficiently decrease intestine-liver circulation

protect scathing liver cell and accelerate jautice to fade away.

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