Objective: To observe the effect of tripterygium wilfordii tablets combined tazarotene in the treatment of psoriasis vulgaris in patients.Method: One hundred sixteen cases of psoriasis vulgaris patients were randomly divided into the observation group and the control group

58 cases in each group.Two groups were given topical tacalcitol ointment

bid;0.05% tazarotene gel

1 times a day

before going to bed externally.Observation group was treated with tripterygium wilfordii polyglycoside tablet 30 mg each time

tid.The 2 groups were treated for 4 weeks as 1 courses of treatment.After 3 courses of treatment clinical effect was observed for before and after treatment

including tumor necrosis factor-α（TNF-α）

expression of vascular endothelial growth factor（VEGF）

interleukin 18（IL-18） and dry skin

itching

erythema

burning and other adverse reaction.Result: In observation group basic recovery rate was 51.72%

total effective rate was 94.83%;in control group the basic recovery rate was 37.93%

the total efficiency of 82.76%.Two groups showed significant basic recovery rate and the total efficiency rate（P<0.05）.TNF-α

VEGF

IL-18 before and after treatment in 2 groups both showed difference（P<0.05）.After the treatment

the difference between two groups was significant（P<0.05）.In observation group the incidence of adverse reactions was 10.34%

in control group the incidence was 8.62% without significant difference.Conclusion: The effect of Tripterygium wilfordii tablets combined tazarotene in the treatment of psoriasis vulgaris has good clinical curative effect

can reduce the level of serum TNF-α

VEGF

IL-18 levels

so that psoriasis patients immune regulation tends to normal

so as to achieve the purpose of treating disease.