Objective:To investigate the change in hemorheological parameters and components of erythrocyte membrane of the senile patients of coronary heart disease with qi deficiency and blood stasis.Method: Eighteen coronary heart disease patients with qi deficiency and blood stasis

thirteen healthy old people and ten healthy young people were divided into coronary patient group and healthy old people control group and healthy young people control group.Many indexes

including biochemical indicators of plasma

whole blood viscosity

plasma viscosity

erythrocyte deformability and the content of cholesterol

sialic acid

hydrosulphonyl

MDA

activity of SOD

Na+-K+-ATP enzyme activity of erythrocyte membrane were determined.Result: The whole blood viscosity at low

middle and high shear rates of the coronary heart disease group were [（24.08±4.85）

（8.48±1.81）

（5.51±1.27） mPa · s] respectively.Compared with healthy elderly group [（20.26±2.76）

（7.36±0.81）

（4.71±0.54） mPa · s] and healthy young group [（17.04±5.26）

（6.53±1.38）

（4.16±0.61） mPa · s]

the whole blood viscosity of the coronary heart disease group was increased significantly（P<0.05

P<0.01）.The plasma viscosity of the coronary patient [（1.56±0.078） mPa · s] was significantly higher than that of the healthy elderly group [（1.26±0.095） mPa · s] and healthy young group [（1.25±0.053） mPa · s]（P<0.01

P<0.05）.The red cell deformability index of the coronary heart disease group under 600 s-1（46.55±2.37） was lower than that of healthy elderly group（49.25±3.70）（P<0.05）;Under 800

1000 s-1

the coronary heart disease group（47.70±2.54 and 48.93±2.46） were lower than those of healthy young group（52.35±2.43

53.07±2.57）（P<0.05）.The contents of cholesterol in erythrocyte membrane of the coronary heart disease group（6.09±1.44） μmol · mg-1 were significantly higher than that of the healthy elderly group（5.07±1.44） μmol-1 · mg-1（P<0.05）.The contents of sialic acid of coronary heart disease group（2.01±0.42） mmol · mg-1 were significantly lower than that of the healthy young group（2.82±0.70） mmol · mg-1.And hydrosulphonyl in erythrocyte membrane in the coronary heart disease group（0.039±0.019） mmol · mg-1 was significantly lower than that of the healthy elderly group（0.059±0.022） mmol · mg-1

（P<0.05） and the healthy young group（0.070±0.011） mmol ·mg-1

（P<0.01）

SOD and Na+-K+-ATP enzyme activities of erythrocyte membrane were decreasing and the content of MDA was increasing.However

there were no statistically difference.Conclusion: The whole blood viscosity and plasma viscosity in the senile patients with qi deficiency and blood stasis are increased significantly and the red cell deformability is decreased distinctly.The mechanism may be related to the increase in membrane sialic acid and cholesterol

and the decrease in hydrosulphonyl.