Objective:To investigate the regulating effects of dayflower（Commelina communis L.） on blood lipids metabolism and the anti-oxidative capability in hyperlipidemia mice.Method: KM male mice were randomly divided into six groups: normal control group

model group

Simvastatin group（4 mg · kg）

dayflower high dose group（16 g · kg-1）

middle dose group（8 g · kg-1） and low dose group（4 g · kg-1）.The normal control mice were given pure water

and the mice of other five groups were given lipid emulsion 0.02 mL · g-1daily and subjected to intragastric administration simultaneously for 14days.After the last medication

all mice were sacrificed

blood lipids

anti-oxidative enzymes

malondiadehyde（MDA） content in serum

liver and brain were determined respectively.Atherogenic index（AI） was calculated.Result: Compared with the model

dayflower extracts 4-16 g · kg-1 lowered serum total cholesterol（TC）

low-density lipoprotein cholesterol（LDL-C） levels

AI and malondiadehyde（MDA） content in serum

liver and brain

and increased high-density lipoprotein cholesterol（HDL-C） levels（P<0.05

P<0.01）;dayflower extracts 8-16g · kg-1 increased superoxide disrnutase（SOD） and glutathioneperoxidaes（GSH-Px） activities in serum

liver and brain（P<0.05

P<0.01）.Conclusion: Dayflower（C.communis） could regulate lipids metabolic disorder

enhance the anti-oxidative capability and inhibit the lipid peroxidation in mice with hyperlipidemia.