Protection Effect of Saffower Yellower in Acute Myocardial Ischemic Rats

ZHANG Yuan; CHEN Chen; LIU Qian; QIN Yuan-yuan; GAO Hua

doi:10.13422/j.cnki.syfjx.2012.16.024

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Protection Effect of Saffower Yellower in Acute Myocardial Ischemic Rats

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- Protection Effect of Saffower Yellower in Acute Myocardial Ischemic Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 16, Pages: 282-284(2012)
- 作者机构：
  
  中国食品药品检定研究院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.16.024
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]张媛,陈晨,刘倩,秦媛媛,高华.红花黄色素对急性心肌缺血大鼠的保护作用[J].中国实验方剂学杂志,2012,18(16):282-284.

ZHANG Yuan, CHEN Chen, LIU Qian, et al. Protection Effect of Saffower Yellower in Acute Myocardial Ischemic Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 282-284.
[1]张媛,陈晨,刘倩,秦媛媛,高华.红花黄色素对急性心肌缺血大鼠的保护作用[J].中国实验方剂学杂志,2012,18(16):282-284. DOI： 10.13422/j.cnki.syfjx.2012.16.024.

ZHANG Yuan, CHEN Chen, LIU Qian, et al. Protection Effect of Saffower Yellower in Acute Myocardial Ischemic Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 282-284. DOI： 10.13422/j.cnki.syfjx.2012.16.024.

摘要

目的:观察红花黄色素对急性心肌缺血大鼠心肌组织中丙二醛（MDA）、超氧化物歧化酶（SOD）的影响及对心肌组织损伤的保护作用。方法:大鼠分为5组

阳性药组（丹参注射液

含生药3.7520g.kg-1）、红花黄色素高、低剂量组（含生药80

4020mg.kg-1）、正常对照组（生理盐水）、模型组（生理盐水）

每组13只

均ip

连续720d

于第8天ip垂体后叶素（Pit）2020U.kg-1造模成大鼠急性心肌缺血模型

测定左心室心肌组织中SOD

MDA的变化以及观察心肌梗死面积的变化。结果:在造模成功的前提下

红花黄色素高、低剂量组与模型组比

可显著增加大鼠左心室心肌中SOD活性[（47.57±11.52）vs（25.97±7.73）U.mg-1

P<0.01;（41.28±11.97）vs（25.97±7.73）U.mg-1

P<0.05]

并明显降低MDA含量[（0.29±0.08）vs（1.40±0.26）nmol.mg-1

P<0.01;（0.45±0.15）vs（1.40±0.26）nmol.mg-1

P<0.01]

且呈量效关系;经TTC染色

红花黄色素高剂量组梗死区面积明显小于模型组[（32.20±2.2）%vs（43.84±6.3）%

P<0.05]。结论:红花黄色素注射液对Pit所致的急性心肌缺血大鼠有保护作用

其作用机制可能与抗氧化有关。

Abstract

Objective:To investigate the regulatory effects of saffower yellower on superoxide dismutase（SOD）

malondialdehyed（MDA） and infarction area in acute myocardial ischemic rats.Method: Rats were randomly divided into 5 groups（n=13 each）: the controls and the model group（normal saline

ip）

the positive controls [Danshen injection

3.75 g · kg-1

ip) and Saffower Yellower high dose and low dose groups（80

40 mg ·kg-1 ip）.The treatment lasted for 7 days respectively.On the 8th day

rats were injected with pituitrin（20 U · kg-1

ip） to induce acute myocardial ischemia.Then the SOD activity and MDA concentration in heart tissues and heart infarction areas in rats were detected.Result: In comparison to group

modle saffower yellower 80 mg · kg-1group significantly enhanced SOD activity [（47.57±11.52） vs（25.97±7.73） U ·mg-1

P<0.01];[（41.28±11.97） vs（25.97±7.73） U · mg-1

P<0.05] and suppressed MDA concentration [（0.29±0.08） vs（1.40±0.26） nmol · mg-1

P<0.01];[（0.45±0.15） vs（1.40±0.26） nmol · mg-1

P<0.01] in left ventricle tissues.The infarction areas were decreased in 80 mg · kg-1 saffower yellower group compared to model group [（32.20±2.2）% vs（43.84±6.3）%

P<0.05].Saffower yellower dose dependently reversed these pathological changes significantly.Conclusion: Saffower yellower has protective effect to the pathological impairment in rats with acute myocardial ischemic induced by pituitrin.This is likely related to its anti-oxidation action.

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