Recent Advances on Chinese Medicine and Active Ingredients in Ameliorating Insulin Resistance via GLUT4 Translocation

HUANG Ming-qing1; XU Wen1; CHU Ke-dan1; LU Jin-jian2; CHEN Xiu-ping3; WANG Yi-tao3

doi:10.13422/j.cnki.syfjx.2012.16.028

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Recent Advances on Chinese Medicine and Active Ingredients in Ameliorating Insulin Resistance via GLUT4 Translocation

更新时间：2024-09-23

- Recent Advances on Chinese Medicine and Active Ingredients in Ameliorating Insulin Resistance via GLUT4 Translocation
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 16, Pages: 343-346(2012)
- 作者机构：
  
  1. 福建中医药大学药学院
  2. 浙江中医药大学生命科学学院
  3. 3. 中药质量研究国家重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.16.028
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]黄鸣清,许文,褚克丹,陆金健,陈修平,王一涛.基于GLUT4转位的中药及活性成分改善胰岛素抵抗研究进展[J].中国实验方剂学杂志,2012,18(16):343-346.

HUANG Ming-qing1, XU Wen1, CHU Ke-dan1, et al. Recent Advances on Chinese Medicine and Active Ingredients in Ameliorating Insulin Resistance via GLUT4 Translocation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 343-346.
[1]黄鸣清,许文,褚克丹,陆金健,陈修平,王一涛.基于GLUT4转位的中药及活性成分改善胰岛素抵抗研究进展[J].中国实验方剂学杂志,2012,18(16):343-346. DOI： 10.13422/j.cnki.syfjx.2012.16.028.

HUANG Ming-qing1, XU Wen1, CHU Ke-dan1, et al. Recent Advances on Chinese Medicine and Active Ingredients in Ameliorating Insulin Resistance via GLUT4 Translocation[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 343-346. DOI： 10.13422/j.cnki.syfjx.2012.16.028.

摘要

对中药通过调控葡萄糖转运蛋白4（glucose20transporter204

GLUT4）转位而改善胰岛素抵抗（insulin20resistance

IR）的研究进展进行总结。GLUT4转位研究对IR的机制研究以及药物作用靶点的选择都具有重要意义。本文主要从磷脂酰肌醇3-激酶/非典型蛋白激酶C/蛋白激酶B（PI3K/PKC/Akt）

AMP活化蛋白激酶（AMP-activated20protein20kinase

AMPK）等关键途径

介绍各种中药活性成分、单方及复方通过调控GLUT4转位对IR的改善作用及机制

为防治IR中药的临床合理使用及新药开发提供参考。

Abstract

To summarize the research progress in the treatment of insulin resistance（IR） via glucose transporter 4（GLUT4） translocation with Chinese medicine.Translocation of GLUT4 to plasma membrane plays a key role in regulating whole body glucose homeostasis

and experiments carried out in GLUT4 translocation might give significant results on IR mechanism and drug targets screening.In order to facilitate the clinical rational treatment of IR and develop new potential drug from Chinese medicine

this review will assess the current research status in the treatment of IR via GLUT4 translocation with Chinese medicine including active ingredients

single drug and compound preparations

which mainly via several key pathways such as PI3K/ PKC/ Akt and AMP-activated protein kinase（AMPK）.

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Related Author

HUANG Ming-qing

XU Wen

CHU Ke-dan

LU Jin-jian

CHEN Xiu-ping

WANG Yi-tao

FU Yongsheng

TAN Mingyue

Related Institution

Shandong University of Traditional Chinese Medicine（TCM）

Affiliated Hospital of Shandong University of TCM

School of Health Science，Guangdong Pharmaceutical University

College of Pharmacy，Guangzhou Health Science College

School of Pharmacy，Guangdong Pharmaceutical University

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