Influence of Ganoderma lucidum Triterpenoids on Learning Memory Function and ACh Content in Alzheimer Disease Model Rat

ZHANG Yue; LUO Jun; HUANG Neng-hui; ZHANG Xiao-yi

doi:10.13422/j.cnki.syfjx.2012.16.032

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Influence of Ganoderma lucidum Triterpenoids on Learning Memory Function and ACh Content in Alzheimer Disease Model Rat

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- Influence of Ganoderma lucidum Triterpenoids on Learning Memory Function and ACh Content in Alzheimer Disease Model Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 16, Pages: 172-175(2012)
- 作者机构：
  
  贵阳医学院药理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.16.032
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]张玥,罗俊,黄能慧,张小毅.灵芝三萜类化合物对AD大鼠学习记忆能力和ACh含量的影响[J].中国实验方剂学杂志,2012,18(16):172-175.

ZHANG Yue, LUO Jun, HUANG Neng-hui, et al. Influence of Ganoderma lucidum Triterpenoids on Learning Memory Function and ACh Content in Alzheimer Disease Model Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 172-175.
[1]张玥,罗俊,黄能慧,张小毅.灵芝三萜类化合物对AD大鼠学习记忆能力和ACh含量的影响[J].中国实验方剂学杂志,2012,18(16):172-175. DOI： 10.13422/j.cnki.syfjx.2012.16.032.

ZHANG Yue, LUO Jun, HUANG Neng-hui, et al. Influence of Ganoderma lucidum Triterpenoids on Learning Memory Function and ACh Content in Alzheimer Disease Model Rat[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 172-175. DOI： 10.13422/j.cnki.syfjx.2012.16.032.

摘要

目的:探讨灵芝三萜类化合物（ganoderma lucidum triterpenoids

GLT）对阿尔茨海默病（Alzheimer disease

AD）的防治作用及其机制。方法:将自然衰老模型大鼠60只随机均分为6组

模型组（NS 10 mL.kg-1）、GLT低、中、高剂量组（0.25

0.5

1.0 g.kg-1）、阳性对照组（健脑胶囊0.38 g.kg-1）及溶媒对照组（食用油10 mL.kg-1）;5月龄大鼠10只为正常对照组（NS 10 mL.kg-1）。连续ig给药60 d后

Morris水迷宫检测大鼠学习记忆能力;光化学法检测脑组织乙酰胆碱酯酶（AChE）、乙酰胆碱转移酶（ChAT）活性。结果:自然衰老模型大鼠逃避潜伏期延长、搜索距离增加

探索时间及探索距离百分比减少

显示学习记忆障碍

脑组织AChE活力升高、ChAT活力降低。自然衰老模型大鼠用GLT ig 60 d后

学习记忆成绩明显提高

AChE活力降低、ChAT活力升高。结论:GLT对AD有防治作用

其作用机制可能和提高脑内乙酰胆碱（ACh）含量有关。

Abstract

Objective:To observe the protective effects and mechanism of Ganoderma lucidum triterpenoids（GLT） in Alzheimer disease model animal.Method: After Morris water maze

60 natural aging rats（24 month） qualified and screened were randomly divided into 6 groups（n=10）

model group（NS 10 mL · kg-1）

GLT low dose group（0.25 g · kg-1）

GLT middle dose group（0.5 g · kg-1）

GLT high dose group（1.0 g · kg-1）

positive group[Jiannao Jiaonang（JNJN） 0.38 g·kg-1] and solvent group（oil 10 mL · kg-1）

while 10 young rats（5 month） were selected as a control group.Then the intragastric administration was used.After being treated with GLT for 60 days

the learning and memory function were tested by Morris water maze

the activity of total acetylcholinesterase（AChE）

choline acetyl transferase（ChAT） in brain were examined by chemistry detecting kits.Result: The model animals showed worse ability in learning and memory compared with the control.The activity of AChE increased

while the activity of ChAT decreased in model animals compared with the control.GLT significantly improved the changes mentioned above（P<0.05）.Conclusion: GLT can improve the learning and memory dysfunction in aging model rats by increasing ACh content in brain.

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Liaoning University of Traditional Chinese Medicine

Department of Neurology,the First Hospital,Harbin Medical University

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School of Basic Medical Sciences， Hubei University of Chinese Medicine

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