Objective:To investigate protective effect of solid preparation of Xingnaojing（XNJ） in middle cerebral artery occlusion（MCAO） model in rats

and explore related mechanism.Method: Cerebral middle artery was occluded with nylon suture to establish permanent middle cerebral artery occlusion（pMCAO） model.Rats with occlusion were randomly divided into model group

XNJ 12

25

50 mg · kg-1 groups

and Butylphthalide（NBP） 70 mg · kg-1 group

which were ig administered for 12 days

taking rats underwent same procedure except artery occlusion as the sham group.At day of 3

6

9

12

14 from the occlusion

four different neurological tests were applied to all animals: neurological defects score

beam-walking test

tape-removal test

and pulling-force test

with regard to detection of sensorimotor defects

motor coordination defects

and strength of forelimbs.At the 14th day

superoxide dismutase（SOD） activity and malondialdehyde（MDA） content in ischemic cerebral tissues were measured after neurological tests.Result: Compared with the sham group

there were obvious neurological defects in pMCAO model rats.At the 3rd day after occlusion

score of beam-walking test in the model group reduced by 65%（P<0.01）

time for tape-removing increased 13.9 times（P<0.01）

as well as strength of forelimbs reduced to 39.7%（P<0.01）.From 6th day to 14th day after occlusion

compared with the model group

in the 12

25

50 mg · kg-1 dose-groups of XNJ

neurological defects scores reduced（P<0.05

P<0.01）

scores for beam-walking test improved（P<0.05

P<0.01）

time for tape-removing shortened（P<0.05

P<0.01）

strength of forelimbs increased（P<0.05

P<0.01）.In addition

content of MDA in the ischemic brain tissue of all dose-groups of XNJ significantly reduced（P<0.01）.Conclusion: Solid preparation of XNJ has protective effect on permanent cerebral ischemia model in rats.In early convalescence after pMCAO

it is able to improve recovery of neurological defects in rat

which might relate to its inhibition on generation of MDA to alleviate oxidative stress.