FANG Mei-shan1, ZHANG Hong-ying2. Effects of Extract from Semen Persicae on SOD,GSH-Px Activity and MDA Contents of Brain Tissue in Mice Dementia Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 236-238.
FANG Mei-shan1, ZHANG Hong-ying2. Effects of Extract from Semen Persicae on SOD,GSH-Px Activity and MDA Contents of Brain Tissue in Mice Dementia Model[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 236-238. DOI: 10.13422/j.cnki.syfjx.2012.16.048.
Effects of Extract from Semen Persicae on SOD,GSH-Px Activity and MDA Contents of Brain Tissue in Mice Dementia Model
Objective:To study the effects of ethanol extract from Semen Persicae on superoxide dismutase(SOD)
glutathione peroxidase(GSH-Px) activity and malondialdehyde(MDA) contents of brain tissue in the mice dementia model b induced by AlCl3.Method: To establish the mice dementiamodel of AlCl3was ig given.They were divided into 5 groups: the control group
the model group and the doses groups of high
middle and low extracts(2.4
1.2
0.6 g · kg-1) from Semen Persicae randomly
10 of each group.And modeling mice were ig given corresponding drugs after 40 d continuously
then they were sacrificed.SOD
GSH-Px activity and MDA contents of brain tissue were measured in dementia mice.Result: In the model group activity of SOD and GSH-Px of brain tissue were decreased
the contents of MDA of brain tissue was increased compared with the control group.The ethanol extracts groups from Semen Persicae could obviously increase activity of SOD and GSH-Px of brain tissue and decrease the contents(P<0.01
P<0.05)of MDA of brain tissue compared with the model group.Conclusion: The ethanol extract from Semen Persicae has scavenging oxygen free radicals and anti-oxidation effects.
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Related Author
FANG Mei-shan
ZHANG Hong-ying
CHENG Yu-xin
LV Jin-fang
NING Kang-jian
HU Chun-hui
LI Tao
LIU Hai-yun
Related Institution
Guangdong Second Prowincial Traditional Chinese Medicine Hospital
First People’s Hospital of Shunde District
First People’s Hospital of Foshan
The R&D Center of Drug for Renal Diseases,Guangzhou Consun Pharmaceutical Co.,Ltd