ZHANG Ke-feng1, DU Zheng-cai2, GAO Ya1, et al. Effect and Mechanism of Polygonum perfoliatum on Hepatic Fibrosis Induced by Dimethylnitrosamine in the Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 242-245.
ZHANG Ke-feng1, DU Zheng-cai2, GAO Ya1, et al. Effect and Mechanism of Polygonum perfoliatum on Hepatic Fibrosis Induced by Dimethylnitrosamine in the Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 242-245. DOI: 10.13422/j.cnki.syfjx.2012.16.050.
Effect and Mechanism of Polygonum perfoliatum on Hepatic Fibrosis Induced by Dimethylnitrosamine in the Rats
Objective:To observe the therapeutic effect of Polygonum perfoliatum in hepatic fibrosis(HF) induceded by dimethylnitrosamine(DMN) in rats.Method: Rats were given the DMN to establish hepatic fibrosis model
and then given different dose of P.perfoliatum.The liver was used to histopathological analysis.And hepatic levels of transforming growth factor-beta 1(TGF-β1)
serum hyaluronic acid(HA)、laminin(LN)
procollagen type Ⅲ(PCⅢ)
type Ⅳ collagen(Ⅳ-C) were also measured.Result: High and middle dose of P.perfoliatum reduced the content of serum HA
LN
PCⅢ and Ⅳ-C(P<0.05 or P<0.01)and TGF-β1 level in liver(P<0.05 or P<0.01)
and the low dose had no effect.Conclusion: The P.perfoliatum attenuates progression of hepatic fibrosis induced by DME in rats.The mechanism is possibly related to suppressing hepatic fibrosis through protecting liver and suppressing the expression of TGF-β1.