Objective:To discuss the mechanism of the fracture healing by Gujian granule which may promote the express of transforming growth factor-β1（TGF-β1）and bone morphogenetic protein-2（BMP-2）

and the change of bone gamma-carboxyglutamic-acid-containing proteins（BGP）and blood rheological behavior.Method: The rabbit model of radius fracture was establishs.The modelinng rabbits were randomly definited into five groups:model group A

Shangke Jiegu Pian group（200 mg · kg-1）

low dose of Gujian granule group（0.4 g · kg-1）

middle dose of Gujian granule group（0.81 g · kg-1） and high dose of Gujian granule group（1.62 g · kg-1）

25 rabbites each group.The oral administration was started at second day of modeling

once per day.After 1

2

3

4

6 weeks of modeling

respectively

material bone tissue were collected to measure the expression of TGF-β1 and BMP-2 by histochemistry stains and graph analysis;and radio immunity analysis was used to detect the level of BGP in peripheral venous blood at the same time and the indexes of blood rheology were measured during the second week.Result: The peak of expression intensity of TGF-β1 and BMP-2 in administrated group appeared at second week

the peak in modeling group appeared at third week.The sequence was group D>group E>group C>group B>group A.In each group peak of BGP appeaed at the week 3

and the sequence was group D>group E>group C>group B>group A.At second week

whole blood viscosity at high and low shear was significantly different（P<0.01 or P<0.05）.The erythrocyte sedimentation rate and blood cell press volume and viscosity of plasma were significantly different（P<0.01）.Conlusion:Gujian granule can promote the fracture healing by improving expression of TGF-β1 and BMP-2

BGP level and indexes of blood rheology.