Effect of Azone on in vivo Percutaneous Absorption of Tetrahydropalmatine from Guping Cataplasm

ZHANG Chao

doi:10.13422/j.cnki.syfjx.2012.16.056

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Effect of Azone on in vivo Percutaneous Absorption of Tetrahydropalmatine from Guping Cataplasm

更新时间：2024-09-23

- Effect of Azone on in vivo Percutaneous Absorption of Tetrahydropalmatine from Guping Cataplasm
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 16, Pages: 14-15(2012)
- 作者机构：
  
  山东中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.16.056
  CLC： R283.6
- Published：2012
- 稿件说明：
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[1]张超.氮酮对骨平巴布膏中延胡索乙素在体经皮吸收的影响[J].中国实验方剂学杂志,2012,18(16):14-15.

ZHANG Chao. Effect of Azone on in vivo Percutaneous Absorption of Tetrahydropalmatine from Guping Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 14-15.
[1]张超.氮酮对骨平巴布膏中延胡索乙素在体经皮吸收的影响[J].中国实验方剂学杂志,2012,18(16):14-15. DOI： 10.13422/j.cnki.syfjx.2012.16.056.

ZHANG Chao. Effect of Azone on in vivo Percutaneous Absorption of Tetrahydropalmatine from Guping Cataplasm[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 14-15. DOI： 10.13422/j.cnki.syfjx.2012.16.056.

摘要

目的:探讨氮酮对骨平巴布膏中延胡索乙素在体经皮吸收的影响。方法:采用膏体剩余量法

测定延胡索乙素的剩余量

模拟延胡索乙素透皮吸收的动力学方程式。结果:延胡索乙素的透皮吸收表现为一级动力学模式

随氮酮用量的增加

透皮吸收量越高

吸收速率越大。结论:氮酮质量分数3%和5%的制剂透皮吸收量均较大

且无显著差异

结合时滞影响的考虑

确定氮酮用量3%。

Abstract

Objective:To investigate influence of azone on in vivo percutaneous absorption of tetrahydropalmatine from Guping cataplasm.Method: Paste residual quantity method was used by determining remnant amount of tetrahydropalmatine

its kinetic equation of transdermal absorption was simulated.Result: Transdermal absorption of tetrahydropalmatine showed first-order kinetics

rate of absorption and absorbed dose were enhanced when dosage of azone raised.Conclusion: There was no significant deviation between mass fraction of azone 3% and 5%

which both had great absorbed dose

consideration by combining with effect of lag time

we determined the amount of azone 3%.

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Related Author

ZHANG Chao

LIN Gui-tao1

QI Hong2

SHENG Hua-gang1

WANG Li-sheng

LAI Bao-lin

WU Yang

ZHOU Li-ling

Related Institution

Department of Pharmaceutics,Guangzhou University of Chinese Medicine

National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine， Jiangxi University of Chinese Medicine

Jiangxi Bencao Tiangong Technology Co. Ltd.

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Jiangxi Jinfurong Pharmaceutical Co. Ltd.， CSPC Pharmaceutical Group Co. Ltd.

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