Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology

LI Jie; YIN Rong-li; LI Dong-fen; LV Yi-ping; ZHAO Ming-qin; LI Kai

doi:10.13422/j.cnki.syfjx.2012.16.067

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Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology

更新时间：2024-09-23

- Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 16, Pages: 49-53(2012)
- 作者机构：
  
  成都中医药大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.16.067
  CLC： R283
- Published：2012
- 稿件说明：
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[1]李杰,尹蓉莉,李东芬,吕懿平,赵明琴,李开.星点设计-效应面法优化夏天无总生物碱微孔渗透泵片处方[J].中国实验方剂学杂志,2012,18(16):49-53.

LI Jie, YIN Rong-li, LI Dong-fen, et al. Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 49-53.
[1]李杰,尹蓉莉,李东芬,吕懿平,赵明琴,李开.星点设计-效应面法优化夏天无总生物碱微孔渗透泵片处方[J].中国实验方剂学杂志,2012,18(16):49-53. DOI： 10.13422/j.cnki.syfjx.2012.16.067.

LI Jie, YIN Rong-li, LI Dong-fen, et al. Optimization of Microporosity Osmotic Pump Tablet Prescription of Total Alkaloids from Corydalis decumbens by Central Composite Design-Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(16): 49-53. DOI： 10.13422/j.cnki.syfjx.2012.16.067.

摘要

目的:应用星点设计-效应面法优化夏天无总生物碱微孔渗透泵片处方。方法:以NaCl用量、致孔剂含量、包衣增质量为自变量

药物累积释药量及累积释放量曲线的线性相关系数（r）为因变量

应用Design Expert对处方进行优化

并对优化处方进行验证。结果:最优处方为NaCl用量34 mg

致孔剂质量分数99%

包衣增质量4%;优化处方呈零级释放特性。结论:通过星点设计-效应面法成功建立了处方优化模型

实现了夏天无总生物碱微孔渗透泵片的处方筛选。

Abstract

Objective:To optimize microporosity osmotic pump tablet formulation of total alkaloids from Corydalis decumbens by central composite design-response surface methodology.Method: With dosage of NaCl

pore-forming agent content

coating weight gain as independent variables

the linear correlation coefficient（r） of cumulative release curve and drug cumulative release amount as dependent variables

prescription was optimized by Design Expert

and verified this optimized formulations.Result: Optimum formulation was as follows:the dosage of NaCl 34 mg

the mass fraction 99%

coating weight gain 4%;This optimized formulation showed zero-order release property.Conclusion: A formulation optimization model was successfully established by central composite design-response surface methodology

thereby prescription screening of microporosity osmotic pump tablet formulation of total alkaloids from C.decumbens was achieved.

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Related Author

Li Jie

YIN Rong-li

LI Dong-fen

LV Yi-ping

ZHAO Ming-qin

LI Kai

Shuang CHENG

Xiang-yun CHEN

Related Institution

Jiangxi University of Traditional Chinese Medicine

Ethnic Medicine School, Chengdu University of Traditional Chinese Medicine

Tibetan Medical College, Qinghai University

Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine, Key Laboratory of Scientific Preparation for Clinical Effective Prescription of State Administration of Traditional Chinese Medicine

Drug Research Center for Nephropathy,Guangzhou Consun Pharmaceutical Co.Ltd

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