Objective:To establish capillary electrophoresis fingerprints（CEFPs） of Tianwang Buxin Wan（TWBXW）.Method: Square optimization method was used to choose the background electrolyte（BGE） and index of chromatographic fingerprint（F） was applied to optimize the CEFPs conditions.The CEFPs were obtained by using a 75 cm×75 μm I.D.（the effective length of 63 cm） uncoated fused silica capillary with 50 mmol · L-1 sodium borate-50 mmol · L-1 disodium hydrogen phosphate（3∶5） as the BGE.The running voltage was 15 kV while the detection wavelength was set at 203 nm.The 12 batches of TWBXW were identified by hierachical cluster analysis

and the referential capillary electrophoresis fingerprint（RCEFP） was synthesized from 11 batches of TWBXW according to the results of classification.Taking the RCEFP for the qualified model

the whole 12 batches of TWBXW were evaluated by systematic quantified fingerprint method（SQFM）.Result: Fourteen co-possessing peaks were selected as the CEFPs peaks when taking ferulic acid peak as the referential peak

and the identification results obtained by SQFM indicated that the quality of S2

S6

S7

S10 and S11 were better

S4 and S8 were good

S5 and S9 were moderate

S1 and S3 were common and S12 was defective.Conclusion: The results show that the method established is with good precision and reproducibility

which can be served as a novel reference for the quality control of TWBXW.