Investigation of Absorption Characteristics of Total Saponins from Pulsatilla chinensis in Rat Intestinal Valgus Test

CHEN Zhen-hua1; GUAN Yong-mei3; ZHANG Ni3; OU Shui-ping1; ZHU Wei-feng3; YANG Ming1; YANG Shi-lin3

doi:10.13422/j.cnki.syfjx.2012.18.027

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Investigation of Absorption Characteristics of Total Saponins from Pulsatilla chinensis in Rat Intestinal Valgus Test

更新时间：2024-09-23

- Investigation of Absorption Characteristics of Total Saponins from Pulsatilla chinensis in Rat Intestinal Valgus Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 30-33(2012)
- 作者机构：
  
  1. 成都中医药大学药学院
  2. 江西科技师范大学药学院
  3. 江西中医学院现代中药制剂教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.18.027
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]陈振华,管咏梅,张妮,欧水平,朱卫丰,杨明,杨世林.白头翁总皂苷在大鼠肠外翻试验中吸收特性考察[J].中国实验方剂学杂志,2012,18(18):30-33.

CHEN Zhen-hua1, GUAN Yong-mei3, ZHANG Ni3, et al. Investigation of Absorption Characteristics of Total Saponins from Pulsatilla chinensis in Rat Intestinal Valgus Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 30-33.
[1]陈振华,管咏梅,张妮,欧水平,朱卫丰,杨明,杨世林.白头翁总皂苷在大鼠肠外翻试验中吸收特性考察[J].中国实验方剂学杂志,2012,18(18):30-33. DOI： 10.13422/j.cnki.syfjx.2012.18.027.

CHEN Zhen-hua1, GUAN Yong-mei3, ZHANG Ni3, et al. Investigation of Absorption Characteristics of Total Saponins from Pulsatilla chinensis in Rat Intestinal Valgus Test[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 30-33. DOI： 10.13422/j.cnki.syfjx.2012.18.027.

摘要

目的:考察白头翁总皂苷的肠吸收特性。方法:采用离体外翻肠囊模型研究白头翁总皂苷在不同肠段、不同药物浓度下的肠吸收特性

采用HPLC测定样品中指标成分常春藤皂苷元3-O-α-L-吡喃鼠李糖-（1→2）-[β-D-吡喃葡萄糖-（1→4）]-L-吡喃阿拉伯糖苷的质量浓度。结果:白头翁总皂苷指标成分在各个肠段的吸收无显著性差异

各肠段累积吸收量均随药物质量浓度的增加而增加。结论:白头翁总皂苷在大鼠肠道内不存在特殊的"吸收窗"

可能为被动扩散吸收。

Abstract

Objective:To study on intestinal absorption characteristics of total saponins from Pulsatilla chinensis.Method:Isolated everted gut sac model was used to study on intestinal absorption of total saponins from P.chinensis in different segments and different drug concentration

concentration of ivy sapogenin 3-O-α-L-rhamnopyranosyl-（1→2）-[β-D-glucopyranosyl-（1→4）]-L-pyran Arab glucoside in samples were determined by HPLC.Result:Absorption of index components for total saponins from P.chinensis in different intestinal segments had no significant difference

every intestine segments cumulative absorption increased along with concentration of total saponins from P.chinensis.Conclusion:Absorption of total saponins from P.chinensis may be passive diffusion absorption and didn’t be a special absorption window.

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