Investigation of Transdermal Effect and Transdermal Composition of Volatile Oil from Notopterygium incisum,Angelica pubescens and Pair of Them by GC-MS
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Investigation of Transdermal Effect and Transdermal Composition of Volatile Oil from Notopterygium incisum,Angelica pubescens and Pair of Them by GC-MS
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 18, Pages: 46-51(2012)
LI Yang, WANG Li-feng, LIU Ke-pan, et al. Investigation of Transdermal Effect and Transdermal Composition of Volatile Oil from Notopterygium incisum,Angelica pubescens and Pair of Them by GC-MS[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 46-51.
LI Yang, WANG Li-feng, LIU Ke-pan, et al. Investigation of Transdermal Effect and Transdermal Composition of Volatile Oil from Notopterygium incisum,Angelica pubescens and Pair of Them by GC-MS[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 46-51. DOI: 10.13422/j.cnki.syfjx.2012.18.031.
Investigation of Transdermal Effect and Transdermal Composition of Volatile Oil from Notopterygium incisum,Angelica pubescens and Pair of Them by GC-MS
Objective:To analyze transdermal effect and transdermal composition of volatile oil from Notopterygium incisum
Angelica pubescens and pair of them by GC-MS.Method:Chemical constituents of volatile oil in in vitro transdermal donor cell and receiving cell were identified by GC-MS
The relative contents in percentage were calculated with area normalization method.According to mathematical derivation
relative contents was changed into translation rate
which reflected transdermal effect of every components.Result:After percutaneous absorption
thirty-nine components were identified in N.incisum(93.22%)
twenty-nine in A.pubescens(93.74%) and thirty-six in drug pair of them(92.75%).Main components of percutaneous absorption in N.incisum were 1-terpineol(30.96%)
4-terpineol(28.22%)
borneol(7.10%)
etc;Main components of percutaneous absorption in A.pubescens were o-acetyl-p-methylbenzyl alcohol(55.70%)
trans-oxy-linalool(6.79%)
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7-trimethyl-bicyclic 5-hexene-2-one(4.78%)
etc;Main components of percutaneous absorption in drug pair of them were 1-terpineol(28.86%)
4-terpineol(22.41%)
o-acetyl-p-methylbenzyl alcohol(12.15%)
borneol(5.62%)
etc.Conclusion:Transmission rate of every components in three kinds of volatile oil could be sorted qualitatively of transdermal effect.Transmission rate of 1-terpineol was the most in volatile oil of N.incisum.1
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7-trimethyl-bicyclic 5-hexene-2-one had the most transmission rate in volatile oil of A.pubescens.1-terpineol had the most transmission ratio in volatile oil of drug pair of them.