Comparison of the Liver-protective Effects between Traditional Decoction and Chinese Medicinal Dispensing Granule of Sini San

HE Rong-rong1; LI Qiu-lan3; XIANG Fei-jun2; WU Xiao-ming2; CAO Hui2; YU Liu-rong2; SU Wei-wei1; Kurihara Hiroshi3

doi:10.13422/j.cnki.syfjx.2012.18.057

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Comparison of the Liver-protective Effects between Traditional Decoction and Chinese Medicinal Dispensing Granule of Sini San

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- Comparison of the Liver-protective Effects between Traditional Decoction and Chinese Medicinal Dispensing Granule of Sini San
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 153-156(2012)
- 作者机构：
  
  1. 中山大学生命科学院
  2. 康美药业股份有限公司
  3. 暨南大学中药及天然药物研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.18.057
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]何蓉蓉,李秋兰,向飞军,吴晓明,曹晖,于留荣,苏薇薇,栗原博.四逆散传统饮片汤剂和配方颗粒对两种因素致小鼠肝损伤模型的药效比较[J].中国实验方剂学杂志,2012,18(18):153-156.

HE Rong-rong1, LI Qiu-lan3, XIANG Fei-jun2, et al. Comparison of the Liver-protective Effects between Traditional Decoction and Chinese Medicinal Dispensing Granule of Sini San[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 153-156.
[1]何蓉蓉,李秋兰,向飞军,吴晓明,曹晖,于留荣,苏薇薇,栗原博.四逆散传统饮片汤剂和配方颗粒对两种因素致小鼠肝损伤模型的药效比较[J].中国实验方剂学杂志,2012,18(18):153-156. DOI： 10.13422/j.cnki.syfjx.2012.18.057.

HE Rong-rong1, LI Qiu-lan3, XIANG Fei-jun2, et al. Comparison of the Liver-protective Effects between Traditional Decoction and Chinese Medicinal Dispensing Granule of Sini San[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 153-156. DOI： 10.13422/j.cnki.syfjx.2012.18.057.

摘要

目的:四逆散传统汤剂和配方颗粒是在临床中同时存在的两种用药形式

本研究拟对比研究四逆散传统汤剂和配方颗粒的疏肝解郁药效作用

为四逆散配方颗粒的临床使用提供实验依据。方法:昆明种小鼠随机分为空白组、应激模型组、阳性药组、四逆散传统汤剂低、高剂量（600

1 200 mg.kg-1）组、四逆散配方颗粒汤剂低、高剂量（600

1 200 mg.kg-1）组共7组

每组10只。小鼠连续灌胃给药1周

实验第6天时给予小鼠一次性拘束应激18 h

测定血浆丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平。昆明种小鼠随机分为空白组、粉刺杆菌-脂多糖（Propionibacterium acne-LPS）致肝炎模型组、阳性药组、四逆散传统汤剂低、高剂量（600

1 200 mg.kg-1）组、四逆散配方颗粒汤剂低、高剂量（600

1 200 mg.kg-1）组共7组

每组10只。小鼠尾静脉注射20 mg.kg-1热灭活粉刺杆菌生理盐水溶液5 d后

尾静脉注射5μg.kg-1脂多糖生理盐水溶液

5 h测定血浆ALT

AST水平。结果:与正常对照组相比

应激模型组和P.acnes-LPS的血浆ALT均显著增高（43.4±2.0）U.L-1vs（12.2±2.8）U.L-1

P<0.05;（114.9±23.3）U.L-1 vs（18.8±5.2）U.L-1

P<0.05

AST水平也显著增高。与模型组相比

四逆散传统饮片汤剂和配方颗粒均能显著降低应激负荷和粉刺杆菌-脂多糖升高的血浆ALT和AST水平

但是两药药效没有统计学差异。结论:四逆散传统饮片汤剂和配方颗粒均有较好的保肝作用。

Abstract

Objective:To compare the liver-protective effects between traditional decoction and Chinese medicinal dispensing granule of Sini San.Method:Liver injury models were induced by establishing restraint stress and Propionibacterium acnes-lipopolysaccharide（LPS） in mice.Kunming mice were divided into 7 groups

normal control

stress model

positive control

Sini San decoction（600

1 200 mg · kg-1） and Sini San dispensing granule（600

1 200 mg · kg-1）.Mice were administered for consecutive 6 days and restrained for 18 h.Hepatic function was evaluated by assessing assessing alanine aminotransferase（ALT） and aspartate aminotransferase（AST） level in plasma.Kuming mice were divided into 7 groups

such as normal control

P.acnes-LPS model

positive control

Sini San decoction（600

1 200 mg · kg-1） and Sini San dispensing granule（600

1 200 mg · kg-1）.Mice were injected with 20 mg · kg-1 P.acnes and 5 μg · kg-1 LPS to induce liver injury.Hepatic function was evaluated by ALT and AST level in plasma.Result:Compared with the model groups

the traditional decoction and Chinese dispensing granule of Sini San significantly reduced ALT and AST levels induced by restraint stress or P.acne-LPS.However

there were no significant difference between the two samples.Conclusion:The traditional decoction and Chinese medicinal dispensing granule of Sini San both are effective on improving the liver function in liver-injury mice model.

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Related Author

KURIHARA Hiroshi

SU Wei-wei

YU Liu-rong

CAO Hui

WU Xiao-ming

XIANG Fei-jun

LI Qiu-lan

HE Rong-rong

Related Institution

Department of Physiology,Henan University of Traditional Chinese Medicine

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