Objective:To study on the effect of Siraitiae Fructus extracts from different growth period fruit on postprandial blood glucose levels in mice

and examine the impact on postprandial insulin and α-glucosidase enzyme activity.Method:Kuenming mice were divided into starch load（6 g · kg-1） and glucose load（2 g · kg-1） group

each group consists of 9 subgroups:normal control

starch load or glucose load control

positive control（acarbose 0.01 g · kg-1）

90 days Siraitiae Fructus extracts high

medium and low dose（1

0.5

0.25 g · kg-1）

60 days Siraitiae Fructus extracts high

medium and low dose（1

0.5

0.25 g · kg-1）.The postprandial blood glucose induced by starch and glucose were observed after 7 days Siraitiae Fructus extracts administration

and the postprandial insulin levels were determined via ELISA method.Moreover

the inhibition effect of Siraitiae Fructus extracts on α-glucosidase activity was determined in vitro.Result:All dosage of 90 days and 60 days Siraitiae Fructus extracts inhibited peak value of postprandial blood glucose;all dosage of 90 days Siraitiae Fructus extracts reduced glycemic index induced by starch（P<0.05）

and the glycemic index induced by glucose was reduced at 0.25 g · kg-1（P<0.05）;moreover

0.5 g · kg-1of 60 days Siraitiae Fructus extracts significantly reduced glycemic index induced by starch（P<0.01）

but all dose of 60 days Siraitiae Fructus extracts only demonstrated a trend to reduce the glycemic index induced by glucose.All dose of 90 days Siraitiae Fructus extracts significantly increased postprandial insulin（P<0.001）

and 60 days Siraitiae Fructus extracts increased postprandial insulin dose dependently.The IC50 value of 90 and 60 days Siraitiae Fructus extracts was 11.51 g · L-1 and 2.40 g · L-1

respectively.Conclusion:Mangosteen extract is effectual in the inhibition of the rapid increase of postprandial blood glucose

which are primarily mediated by increasing postprandial insulin levels andα-glucosidase inhibition

there is a difference in hypoglycemic mechanism between Siraitiae Fructus extracts from different growth period fruit.