Effcet of Effective Parts from Musa basjoo on Blood Glucose and Glucose Tolerance in Mice

QIAN Hai-bing; HAO Jun-jie; WANG Xiang-pei

doi:10.13422/j.cnki.syfjx.2012.18.064

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Effcet of Effective Parts from Musa basjoo on Blood Glucose and Glucose Tolerance in Mice

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- Effcet of Effective Parts from Musa basjoo on Blood Glucose and Glucose Tolerance in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 187-189(2012)
- 作者机构：
  
  贵阳中医学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.18.064
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]钱海兵,郝俊杰,王祥培.芭蕉根有效部位对小鼠血糖及糖耐量的影响[J].中国实验方剂学杂志,2012,18(18):187-189.

QIAN Hai-bing, HAO Jun-jie, WANG Xiang-pei. Effcet of Effective Parts from Musa basjoo on Blood Glucose and Glucose Tolerance in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 187-189.
[1]钱海兵,郝俊杰,王祥培.芭蕉根有效部位对小鼠血糖及糖耐量的影响[J].中国实验方剂学杂志,2012,18(18):187-189. DOI： 10.13422/j.cnki.syfjx.2012.18.064.

QIAN Hai-bing, HAO Jun-jie, WANG Xiang-pei. Effcet of Effective Parts from Musa basjoo on Blood Glucose and Glucose Tolerance in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 187-189. DOI： 10.13422/j.cnki.syfjx.2012.18.064.

摘要

目的:研究芭蕉根有效部位对正常小鼠及四氧嘧啶糖尿病小鼠血糖、糖耐量的影响。方法:雄性昆明种小鼠

一次性ip四氧嘧啶200 mg.kg-1建立小鼠糖尿病模型

72 h后测空腹血糖

以血糖值超过10.0 mmol.L-1者为造模成功。造模成功小鼠分为模型组、盐酸二甲双胍组（200 mg.kg-1）及芭蕉根有效部位按高、中、低剂量组（200

100

50 mg.kg-1）治疗14 d

考察芭蕉根提取物对四氧嘧啶糖尿病小鼠血糖的影响

同时测定芭蕉根有效部位对正常小鼠血糖的影响、对糖尿病模型小鼠和正常小鼠糖耐量的影响。结果:血糖与模型组（13.25±1.98）mmol.L-1比较芭蕉根有效部位高剂量可以降低四氧嘧啶模型小鼠血糖（9.88±0.79）mmol.L-1（P<0.05）

对正常小鼠血糖没有影响;与模型组糖耐量比较芭蕉根有效部位（200 mg.kg-1）增加四氧嘧啶模型小鼠糖耐量（P<0.05）;正常小鼠糖耐量实验也表明

与空白组120 min血糖比较（5.89±0.63）mmol.L-1芭蕉根有效部位200 mg.kg-1为（5.10±0.47）mmol.L-1提高正常小鼠糖耐量（P<0.05）。结论:芭蕉根有效部位可以改善四氧嘧啶模型小鼠糖代谢

增加四氧嘧啶模型小鼠及正常小鼠的糖负荷。

Abstract

Objective:To study the effect of effective parts from Musa basjoo（EPM） on blood glucose and glucose tolerance in mice.Method: Diabetic model was induced by intraperitoneal injection of Alloxan once.Diabetic mice were randomly divided into model group

Metformin group and high

middle and low dose of EPM groups（200

100

50 mg · kg-1）.All groups were fed for 14 consecutive days

and then the blood glucose was detected on the fifteenth day.Effect on the glucose tolerance in model and normal mice were detected at the same time.Result: EPM could significantly decrease the blood glucose level of diabetic mice（P<0.05）and ameliorate the glucose tolerance in normal and diabetic mice（P<0.05）

but it had no significant effect on the blood glucose level of normal mice.Conclusion: EPM can significantly decrease the blood glucose level in diabetic mice and ameliorate the glucose tolerance in normal and diabetic mice.

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Related Author

QIAN Hai-bing

HAO Jun-jie

WANG Xiang-pei

ZHAO Bao-sheng

GAO Xiao-yan

LIU Yang

ZHAI Hua-qiang

GUI Hai-shui

Related Institution

Second Affiliated Hospital of Guizhou University of TCM

First Affiliated Hospital of Guizhou University of TCM

Guizhou University of Traditional Chinese Medicine（TCM）

Hubei University of Chinese Medicine

Hubei Provincial Hospital of Traditional Chinese Medicine (TCM)

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