Prevention of Xianti JiangzhiⅠPrescription on Obeseing Induced by Ovariectory in Rats

GAN Guo-xing1; WU Xiao-fang1; MO Xin-min2; ZOU Long2; LI Jing-ping3; LIU Shi-jie2

doi:10.13422/j.cnki.syfjx.2012.18.071

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Prevention of Xianti JiangzhiⅠPrescription on Obeseing Induced by Ovariectory in Rats

更新时间：2024-09-23

- Prevention of Xianti JiangzhiⅠPrescription on Obeseing Induced by Ovariectory in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 214-218(2012)
- 作者机构：
  
  1. 清远市中医院
  2. 湖南中医药大学
  3. 中南大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.18.071
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]甘国兴,吴晓芳,莫新民,邹龙,李劲平,刘仕杰.纤体降脂Ⅰ号预防大鼠去卵巢后肥胖[J].中国实验方剂学杂志,2012,18(18):214-218.

GAN Guo-xing1, WU Xiao-fang1, MO Xin-min2, et al. Prevention of Xianti JiangzhiⅠPrescription on Obeseing Induced by Ovariectory in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 214-218.
[1]甘国兴,吴晓芳,莫新民,邹龙,李劲平,刘仕杰.纤体降脂Ⅰ号预防大鼠去卵巢后肥胖[J].中国实验方剂学杂志,2012,18(18):214-218. DOI： 10.13422/j.cnki.syfjx.2012.18.071.

GAN Guo-xing1, WU Xiao-fang1, MO Xin-min2, et al. Prevention of Xianti JiangzhiⅠPrescription on Obeseing Induced by Ovariectory in Rats[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 214-218. DOI： 10.13422/j.cnki.syfjx.2012.18.071.

摘要

目的:研究纤体降脂Ⅰ号对大鼠去卵巢后肥胖的预防作用

探讨其预防肥胖的作用机制。方法:270 g左右的SD雌性大鼠70只

按体重随机选出假手术组10只

其余采用双侧去卵巢法

建立去卵巢大鼠模型。造模成功后

将大鼠随机分为模型对照组、纤体降脂Ⅰ号高剂量组（13.2 g.kg-1.d-1）、中剂量组（6.6 g.kg-1.d-1）、低剂量组（3.3 g.kg-1.d-1）、曲美组（8.9×10-4g.kg-1.d-1）、己烯雌酚组（2.2×10-5g.kg-1.d-1）

开始灌胃给药干预

连续3周

实验结束后

从大鼠体重、腹脂、Lee’s指数、血脂等方面评价其药效;从血清雌二醇和瘦素含量以及下丘脑瘦素的表达

探讨其作用机制。结果:纤体降脂Ⅰ号能明显抑制模型鼠体重和食量的增长（P<0.05或P<0.01）

降低腹脂含量和Lee’s指数（P<0.05或P<0.01）

有效预防大鼠去卵巢后肥胖;显著降低大鼠血清甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）水平（P<0.05或P<0.01）

有升高高密度脂蛋白胆固醇（HDL-C）的趋势;能明显提高大鼠血清雌二醇水平（P<0.05或P<0.01）。结论:纤体降脂Ⅰ号能够有效控制大鼠体重和食欲

预防大鼠去卵巢后肥胖的发生

降低血脂;提高血清雌激素含量

这可能是其预防大鼠去卵巢后肥胖的机制之一。

Abstract

Objective:In order to investigate the effects of Xianti JiangzhiⅠPrescription in proventing obeseing induced by ovariectory in ratsand explore the possible mechanism.Method:Seventy female SD rats

weighting about 270 g were randomly divided into 7 groups:sham-operated group（sham）

simple ovariectomized group and three treated groups with low（3.3 g · kg-1 · d-1）

middle（6.6 g · kg-1 · d-1） and high（13.2 g · kg-1 · d-1） dosage of Xianti JiangzhiⅠprescription

diethyllstillbestrol group（2.2×10-5g · kg-1 · d-1）

trimetazidine group（8.9×10-4g · kg-1 · d-1）

ten each group.The administration started 10 days after operation and continued for 3 weeks.In the end

the blood samples were collected to measure following indexes:serum estradiol（E2）

blood lipids[total cholesterol（TC）

trigly cerides（TG）

high density lipoprotein cholesterol（HDL-C）

low-density lipoprotein cholesterol（LDL-C）]

leptin

wet weight of fat

et al.Result:Xianti JiangzhiⅠprescription can significantly inhibit the increase of weight and food intake in the model rats（P<0.05 or P<0.01）

decreased the weight of wet abdominal fat

reduce the lees indexes（P<0.05 or P<0.01）

significantly prevented obesity induced by ovariectory

significantly decreased the TG

LDL-C level（P<0.05 or P<0.01）and increased the level of blood estrogen（P<0.05 or P<0.01）.Conclusion:Xianti JiangzhiⅠprescription can significantly prevent obesity induced by ovariectory by;decreasing the blood lipids and increasing the level of blood Estrogen

this may be one of its mechanisms.

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Related Author

GAN Guo-xing

WU Xiao-fang

MO Xin-min

ZOU Long

LI Jing-ping

LIU Shi-jie

TU Wenyan

YE Liqun

Related Institution

Ningbo Municipal Hospital of Traditional Chinese Medicine， Affiliated Hospital Zhejiang Chinese Medical University Ningbo

Xiyuan Hospital， China Academy of Chinese Medical Sciences

Beijing University of Chinese Medicine

School of Traditional Chinese Medicine，Hunan University of Chinese Medicine

Affiliated Hospital of Changchun University of Chinese Medicine

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