Objective:To investigate effects of Erzi Capsule（EZC） on apoptosis genes in rats with spermatogenic failure and to explore the related mechanism of action for treatment of male infertility.Method:Forty male rats were randomly divided in to 4 groups:model group

control group and two EZC dose groups（4.8

2.4 g · kg-1）.The rat model of spermatogenic failure was established by intraperitoneal injection of cyclophosphamide（40 mg · kg-1）.The treatments were lasted for 60 days.TUNEL method was used to determine apoptosis in spermatogenic cells.Bax and Bcl-2 expressions in testis were tested by immunohistochemical method.Result:Compared with the model group

two doses of EZC group decreased apoptosis index [（7.16±1.47）%

（13.83±2.40）% vs（20.50±2.17）%]

lowered Bax expression [（16.01±2.02）

（26.67±1.79） vs（9.94±1.14）] and increased Bcl-2 expression [（40.12±3.06）

（22.87±2.94） vs（16.26±1.03）] significantly（P<0.01）.Conclusion:EZC could downregulate the expression of Bax and upregulation Bcl-2 expression

reduce the incidence of apoptosis in spermatogenic cells.