Effect of Diyu Shengbai Tablets on Bone Marrow Depression Induced by Cyclophosphamide in Mice

JIA Liang-liang1; XI Wei1; JIN Gui-lan1

doi:10.13422/j.cnki.syfjx.2012.18.081

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Effect of Diyu Shengbai Tablets on Bone Marrow Depression Induced by Cyclophosphamide in Mice

更新时间：2024-09-23

- Effect of Diyu Shengbai Tablets on Bone Marrow Depression Induced by Cyclophosphamide in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 18, Pages: 251-254(2012)
- 作者机构：
  
  1. 三峡大学人民医院
  2. 宜昌市第一人民医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2012.18.081
  CLC： R285.5
- Published：2012
- 稿件说明：
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[1]贾亮亮,奚炜,金桂兰.地榆升白片对环磷酰胺致小鼠骨髓抑制的拮抗作用[J].中国实验方剂学杂志,2012,18(18):251-254.

JIA Liang-liang1, XI Wei1, JIN Gui-lan1. Effect of Diyu Shengbai Tablets on Bone Marrow Depression Induced by Cyclophosphamide in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 251-254.
[1]贾亮亮,奚炜,金桂兰.地榆升白片对环磷酰胺致小鼠骨髓抑制的拮抗作用[J].中国实验方剂学杂志,2012,18(18):251-254. DOI： 10.13422/j.cnki.syfjx.2012.18.081.

JIA Liang-liang1, XI Wei1, JIN Gui-lan1. Effect of Diyu Shengbai Tablets on Bone Marrow Depression Induced by Cyclophosphamide in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(18): 251-254. DOI： 10.13422/j.cnki.syfjx.2012.18.081.

摘要

目的:观察地榆升白片对环磷酰胺所致小鼠骨髓抑制的保护作用。方法:Balb/C小鼠24只随机分为空白对照组、模型组、地榆升白片组。腹腔注射环磷酰胺100 mg.kg-1建立骨髓抑制模型

地榆升白片组按100 mg.kg-1灌胃

给药10 d。观察地榆升白片对模型小鼠外周血象、骨髓有核细胞数、骨髓中DNA含量的影响

流式细胞术检测骨髓中各时相细胞周期百分比。结果:模型组小鼠外周血白细胞数、血小板数、骨髓有核细胞数以及骨髓中DNA含量显著降低（P<0.05或P<0.01）;骨髓细胞周期中G0/G1期细胞百分比显著增高

G2/M期细胞百分比显著降低（P<0.05或P<0.01）。地榆升白片可以显著增加模型小鼠外周血白细胞数、骨髓有核细胞数及骨髓中DNA含量

恢复骨髓中各期细胞百分比（P<0.05或P<0.01）。结论:地榆升白片对环磷酰胺致骨髓抑制有显著的改善和恢复作用。

Abstract

Objective:To investigate the poctect function of Diyu Shengbai tabletts on bone marrow depression induced by cyclophosphamide in mice.Method: Twenty-four Balb/C mice

half male and femal

were categorized into three groups.Mice in model group and Diyu Shengbai group were administered cyclophosphamide（Cy）（100 mg · kg-1 once a day for 3 days by intraperitoneal injection） to induce marrow suppression.Diyu Shengbai group was received Diyu Shengbai table treatment（100 mg · kg-1body weight orally once a day for 10 days）.A vehicle treated control group was also arrangeed.The changes of peripheral hemogram

bone marrow nucleated cells（BMCs）

DNA content and bone marrow cell cycle were detected.Result:Cy-treated mice showed a significant decrease in the number of white blood cells

thrombocyte

bone marrow nucleated cell proliferation and the content of DNA in bone（compared with control group

there were significant differences

P<0.05 or P<0.01）.The percentage of G0/G1 phase was increased and the percentage G2/M phase decreased（compared with control group

there were significant differences

P<0.05 or P<0.01）.Diyu Shengbai tablets significantly increased the number of white blood cells

thrombocyte

bone marrow nucleated cell proliferation and markedly increased the percentage of G2/M phase(compared with model group（P<0.05 or P<0.01）.Conclusion:Diyu Shengbai Tablets could improve the hemopoietic function for marrow suppression induced by Cy in mice.

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Related Author

JIA Liang-liang

XI Wei

JIN Gui-lan

CAO Jiarui

FENG Bo

MA Chunzheng

CHEN Weixia

YU Jiangfan

Related Institution

Henan Province Hospital of Traditional Chinese Medicine/The Second Affiliated Hospital of Henan University of Chinese Medicine

The Second Clinical Medical College， Henan University of Chinese Medicine

Xinjiang Key Laboratory of Uighur Medical Prescription，Xinjiang Institute of Traditional Uighur Medicine

Affiliated Hospital of Nanjing University of Chinese Medicine， Jiangsu Province Hospital of Chinese Medicine

The First School of Clinical Medicine of Nanjing University of Chinese Medicine

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