Gubenhuayufang on the Relapse of Ulcerative Colitis

FAN Dong-mei1; RAO Jing2; ZHANG Zheng-zheng1; TAO Shuang-you3; ZHUANG Kun-hai1

doi:10.13422/j.cnki.syfjx.2013.03.006

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Gubenhuayufang on the Relapse of Ulcerative Colitis

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- Gubenhuayufang on the Relapse of Ulcerative Colitis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 272-275(2013)
- 作者机构：
  
  1. 广州中医药大学第一附属医院消化内科
  2. 广州中医药大学
  3. 广州中医药大学脾胃研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.03.006
  CLC： R259
- Published：2013
- 稿件说明：
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[1]樊冬梅,饶晶,张铮铮,陶双友,庄昆海.固本化瘀方干预溃疡性结肠炎复发[J].中国实验方剂学杂志,2013,19(03):272-275.

FAN Dong-mei1, RAO Jing2, ZHANG Zheng-zheng1, et al. Gubenhuayufang on the Relapse of Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 272-275.
[1]樊冬梅,饶晶,张铮铮,陶双友,庄昆海.固本化瘀方干预溃疡性结肠炎复发[J].中国实验方剂学杂志,2013,19(03):272-275. DOI： 10.13422/j.cnki.syfjx.2013.03.006.

FAN Dong-mei1, RAO Jing2, ZHANG Zheng-zheng1, et al. Gubenhuayufang on the Relapse of Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 272-275. DOI： 10.13422/j.cnki.syfjx.2013.03.006.

摘要

目的:探讨固本化瘀方干预溃疡性结肠炎（UC）复发的疗效以及对血清肿瘤坏死因子（TNF-α）水平的影响。方法:将84例UC患者随机分为治疗组44例和对照组40例

治疗组给予固本化瘀方加柳氮磺胺毗啶口服方案治疗;对照组仅给予柳氮磺胺毗啶口服

并以20例健康志愿者作为正常对照组。治疗3个月后观察两组近期临床总体疗效

随访6个月后观察两组复发情况

并检测两组治疗前后以及健康对照组血清TNF-α水平。结果:治疗组近期临床总体疗效优于治疗组（P<0.05）;治疗组复发率明显低于对照组（P<0.05）;治疗组治疗后患者血清TNF-α水平明显高于对照组及健康对照组（P<0.05）

复发患者血清TNF-α水平高于未复发患者

组间存在极显著差异（P<0.01）

治疗后、随访时

治疗组血清TNF-α水平皆显著低于对照组（P<0.05）;但随访时在两组间比较

无显著差异。结论:健脾化瘀法治疗溃疡性结肠疗效显著

并可降低复发率

其抗复发作用机制可能是与抑制外周血炎性因子TNF-α的过度表达相关。

Abstract

Objective:To observe the therapeutic effect of Guben Huayufang for the relapse of ulcerative colitis（UC） and its influence on serum tumor necrosis factor-α（TNF-α）.Method: Eighty-four patients with UC were divided into two groups randomly

44 cases in treatment group treated with the Guben Huayufang plus salazosulfapyridine and 40 cases in control group treated with salazosulfapyridine.And a normal control group with 20 healthy volunteers was set.After three months

the general therapeutic effect of the two groups and the relapse information were observed after 6 months

also the serum TNF-α were detect before and after the therapy in three groups.Result: The therapeutic effect of treatment group is better than control group（P<0.05）;the relapse ratio of treatment group is lower than control group（P<0.05）.After the treatment

the serum TNF-α in treatment group is higher than control group and healthy control group（P<0.05）.And the serum TNF-α in the relapse patients is higher than patients who has not relapsed（P<0.01）.After the treatment

and during the follow-up

the serum TNF-α in treatment group is lower than control group（P<0.05）;but with no difference during the follow-up.Conclusion: The therapeutic effect of Guben Huayufang for UC is significant

and can lower the relapse ratio.The mechanism might be that it can lower the expression of serum TNF-α.

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Related Author

FAN Dong-mei

RAO Jing

ZHANG Zheng-zheng

TAO Shuang-you

ZHUANG Kun-hai

WANG Yan-mei

KANG Mei-qing

CUI Yan-bing

Related Institution

Jiangxi University of Chinese Medicine

College of Food Science and Technology，Nanchang University

School of Life Sciences，Beijing University of Chinese Medicine

School of Basic Medical Sciences， Chengdu University of Traditional Chinese Medicine（TCM）

School of Basic Medical Sciences， Guangzhou University of Chinese Medicine

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