ZHAO Ju-xiang, CHENG Yi, WU Qiong, et al. Determination of Encapsulation Efficiency and Investigation of in vitro Release of Kushenin Sterically Stabilized Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 4-7.
ZHAO Ju-xiang, CHENG Yi, WU Qiong, et al. Determination of Encapsulation Efficiency and Investigation of in vitro Release of Kushenin Sterically Stabilized Liposomes[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 4-7. DOI: 10.13422/j.cnki.syfjx.2013.03.017.
Determination of Encapsulation Efficiency and Investigation of in vitro Release of Kushenin Sterically Stabilized Liposomes
Objective:To determine encapsulation efficiency of kushenin sterically stabilized liposomes(Kushenin-SSL)
and investigate its in vitro release law.Method:Kushenin-SSL was prepared by ethanol injection method
Kushenin-SSL and free kushenin were separated by Sephadex G-50 column
encapsulation efficiency was determined by HPLC.In vitro release law of Kushenin-SSL was investigated by the second method of dissolution in the ’Chinese Pharmacopoeia’(2010 edition).Result:Average encapsulation efficiency of Kushenin-SSL was 83.57%
in vitro release curve of Kushenin-SSL conformed Higuchi equation.Conclusion: Encapsulation efficiency of Kushenin-SSL met requirements of the ’Chinese Pharmacopoeia’(2010 edition)
Determination of Encapsulation Efficiency and Investigation of Release of Kushenin Sterically Stabilized Liposomes
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Related Author
ZHAO Ju-xiang
CHENG Yi
WU Qiong
ZHENG Pin-jin
ZHANG Dong-qing
LIU Rong-fei
XIE Yan
YUAN Xiu-rong
Related Institution
Jilin Agricultural University
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences
Chengde Medical University
Jilin Huakang Pharmaceutical Co. Ltd.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Center of Efficient Utilization of Natural Medicine Resources, High Educational Key Laboratory of Natural Medicinal Pharmacology and Druggability of Guizhou Province, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University