LI Yao-hua1, CAI Le1, ZHONG Ming2, et al. Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 97-100.
LI Yao-hua1, CAI Le1, ZHONG Ming2, et al. Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 97-100. DOI: 10.13422/j.cnki.syfjx.2013.03.040.
Studies on the Content Determination and Preliminary Stability of Formulated Granules of Detoxification and Anti-Leukaemia
Objective:To create a determination method and to explore the preliminary stability of formulated granules of detoxification and anti-leukaemia.Method: HPLC was performed on a C18 column(4.6 mm×250 mm
5 μm) using methanol-0.1%H3PO4(34∶66) as the mobile phase at the detection wavelength of 335 nm to determine scutellarin of barbata.The preliminary stability of three batches samples was also investigated.Result: The linear range of scutellarin was 0.260-2.60μg.The mean recovery was 100.7% with RSD 2.6%(n=6).The preliminary stability tests showed that formulated granules met the specification in the appearance
size
moisture content
load difference
solubility and determination of compliance.Conclusion: The method of determination is feasible
formulated granules could be controlled in quality with good stability.