Determination of Apparent Oil-water Partition Coefficient of Oxysophocarpine

ZHANG Lei1; LI Ting-ting1; CHEN Xiao-jian1; XIE Zhi-yong2

doi:10.13422/j.cnki.syfjx.2013.03.051

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Determination of Apparent Oil-water Partition Coefficient of Oxysophocarpine

更新时间：2024-09-23

- Determination of Apparent Oil-water Partition Coefficient of Oxysophocarpine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 130-132(2013)
- 作者机构：
  
  1. 广州中医药大学中药学院
  2. 中山大学药学院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.03.051
  CLC： R284
- Published：2013
- 稿件说明：
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[1]张蕾,李婷婷,陈孝健,谢智勇.氧化槐果碱表观油水分配系数测定[J].中国实验方剂学杂志,2013,19(03):130-132.

ZHANG Lei1, LI Ting-ting1, CHEN Xiao-jian1, et al. Determination of Apparent Oil-water Partition Coefficient of Oxysophocarpine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 130-132.
[1]张蕾,李婷婷,陈孝健,谢智勇.氧化槐果碱表观油水分配系数测定[J].中国实验方剂学杂志,2013,19(03):130-132. DOI： 10.13422/j.cnki.syfjx.2013.03.051.

ZHANG Lei1, LI Ting-ting1, CHEN Xiao-jian1, et al. Determination of Apparent Oil-water Partition Coefficient of Oxysophocarpine[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 130-132. DOI： 10.13422/j.cnki.syfjx.2013.03.051.

摘要

目的:测定氧化槐果碱在正辛醇-水和正辛醇-缓冲液体系中的表观油水分配系数

为体内吸收研究提供参考。方法:以HPLC-DAD为检测手段

采用摇瓶法测定氧化槐果碱的表观油水分配系数。结果:在（37±1）°C下

氧化槐果碱在正辛醇-水体系中的表观油水分配系数为logPapp=-0.44。在pH 1.2～10.0的磷酸盐缓冲液中

测得logPapp在-0.97～-0.25;当pH<4.5时

受pH影响不显著

表现为亲水性;当pH>4.5时

logPapp随pH增大而逐渐增大。结论:该法可准确、快速测定氧化槐果碱的表观油水分配系数

并借此解析其体内动态。

Abstract

Objective:To determine the apparent oil-water partition coefficient of oxysophocarpine in n-octanol-water and n-octanol-phosphate buffer system

and to provide reference for the absorption study in vivo.Method: The apparent oil-water partition coefficient for oxysophocarpine was performed by using shaking flask method with HPLC-DAD as separation and detection pathway.Result: The apparent oil-water partition coefficient of oxysophocarpine was log Papp=-0.44 in n-octanol-water system at 37 ℃.In pH 1.2-10.0 phosphate buffer solutions

log Papp was in the range of-0.97——0.25.When pH<4.5

there was no significant effect on it by pH.When pH>4.5

log Papp of oxysophocarpine showed the gradual increasing tendency with the increasing of pH.Conclusion: The methods described in the paper can be used to determine the oil-water partition coefficient of oxysophocarpine accurately

and help to predict the intracoporal process.

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