The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever

QU Fei1; CUI Yan-ru2; XU Jing3; XU Guo-liang3; HUANG Li-ping1; YU Ri-yue1

doi:10.13422/j.cnki.syfjx.2013.03.063

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The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever

更新时间：2024-09-23

- The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 184-187(2013)
- 作者机构：
  
  1. 江西中医学院药学院药理学教研室
  2. 江西中医学院基础医学院生理学教研室
  3. 江西中医学院现代中药制剂教育部重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.03.063
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]屈飞,崔艳茹,徐镜,徐国良,黄丽萍,余日跃.麻杏石甘汤解热作用量效关系研究[J].中国实验方剂学杂志,2013,19(03):184-187.

QU Fei1, CUI Yan-ru2, XU Jing3, et al. The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 184-187.
[1]屈飞,崔艳茹,徐镜,徐国良,黄丽萍,余日跃.麻杏石甘汤解热作用量效关系研究[J].中国实验方剂学杂志,2013,19(03):184-187. DOI： 10.13422/j.cnki.syfjx.2013.03.063.

QU Fei1, CUI Yan-ru2, XU Jing3, et al. The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 184-187. DOI： 10.13422/j.cnki.syfjx.2013.03.063.

摘要

目的:观察麻杏石甘汤对内毒性发热SD大鼠的体温及血浆前列腺素E2（PGE2）水平的影响

并探讨其量效关系。方法:将66只大鼠随机分为11组

空白对照组

模型组

剂量1组～剂量9组

每组6只

空白对照组尾静脉注射生理盐水

另10组均采用尾静脉注射内毒素的方法制成发热大鼠模型

分别灌胃相应量生理盐水或麻杏石甘汤。观察比较各组体温和6.0 h体温反应指数（TRI6.0）变化

并测定血浆PGE2水平。结果:与模型组相比

麻杏石甘汤剂量1至剂量9能明显降低发热大鼠的最大温差（ΔTmax）和TRI6.0

麻杏石甘汤存在量效关系

且降温效应为多波折曲线。此外

麻杏石甘汤能剂量依赖性降低血浆PGE2水平。结论:不同剂量麻杏石甘汤对内毒素性发热SD大鼠的解热作用为多波折量效关系。

Abstract

Objective:To investigate on temperature and prostaglandin E2（PGE2） contents in plasma of rats with endotoxic fever in Maxing Shigan Tang

and found the dose-effect relationship.Method: Sixty-six rats were randomly divided into 11 groups

of which with 6: control group

model group

dose 1-dose 9 groups.The control group was injected normal saline

the other group with endotoxin;dose groups were administrated with Maxing Shigan Tang of different doses.ΔTmax and thermal response index（TRI） were observed.The levels of plasma PGE2 was determined.Result: Compared with control group

dose 1-dose 9 group could depress ΔTmax and TRI significantly.The effect had dose-effect relationship and showed many twists and turns.In addition

Maxing Shigan Tang could lower the level of PGE2 with dose-effect.Conclusion: Different doses of Maxing Shigan Tang have antipyretic effect of dose-effect relationship for the many twists and turns to fever rats.

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Related Author

YU Ri-yue

HUANG Li-ping

XU Guo-liang

XU Jing

CUI Yan-ru

QU Fei

HUANG Lu-qi

HE Xi-rong

Related Institution

Shandong University of Traditional Chinese Medicine,Ji’nan

Depatment of Pharmacology,Jiangxi University of Traditional Chinese Medicine

江西中医学院生理学教研室

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