This article summaries the research progress about molecular mechanisms of neural stem cells proliferation.Referring to literatures about molecular mechanisms of neural stem cell（NSCs） proliferation and the intervention of traditional Chinese medicine from CNKI

Wanfang database and PUBMED

it can be found that endogenous NSCs proliferation is regulated by many factors

and closely interrelated with cytokines

for example brain-derived neurotrophic factor（BDNF）

basic fibroblast growth factor（bFGF）

interleukin

and Notch gene

Wnt gene as well as their signaling pathway.All regulatory factors interact with each other and form a sophisticated regulatory network.According to the features and advantages of the multi-component

multi-target and multi-level of traditional Chinese medicine

it is significant to develop drug screening

prescription optimization and innovative drug research in the light of endogenous NSCs proliferation.Traditional Chinese medicine has excellent application prospect in promoting the proliferation of neural stem cells and the treatment of stroke and neurodegenerative diseases.