Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A<sup>y</sup> Transgenic Mice Model of Diabetes Mellitus

ZHENG Yong-qiu; GE Zheng-yan; JIN Long; GUO Yu-jie; YANG Bing; DONG Xiao-xia; LI Hong-kun; REN Ye; LIU Jian-xun

doi:10.13422/j.cnki.syfjx.2013.03.089

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Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus

更新时间：2024-09-23

- Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 175-179(2013)
- 作者机构：
  
  中国中医科学院西苑医院实验研究中心
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.03.089
  CLC： R587.1
- Published：2013
- 稿件说明：
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[1]郑咏秋,葛争艳,金龙,郭宇洁,杨斌,董小霞,李宏坤,任烨,刘建勋.降糖消脂片对KK-A~y糖尿病肥胖小鼠胰岛素受体及底物表达的影响[J].中国实验方剂学杂志,2013,19(03):175-179.

ZHENG Yong-qiu, GE Zheng-yan, JIN Long, et al. Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 175-179.
[1]郑咏秋,葛争艳,金龙,郭宇洁,杨斌,董小霞,李宏坤,任烨,刘建勋.降糖消脂片对KK-A~y糖尿病肥胖小鼠胰岛素受体及底物表达的影响[J].中国实验方剂学杂志,2013,19(03):175-179. DOI： 10.13422/j.cnki.syfjx.2013.03.089.

ZHENG Yong-qiu, GE Zheng-yan, JIN Long, et al. Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 175-179. DOI： 10.13422/j.cnki.syfjx.2013.03.089.

摘要

目的:建立糖尿病肥胖小鼠模型

观察降糖消脂片对模型小鼠胰腺胰岛素受体及底物表达的影响。方法:采用KK-Ay转基因小鼠

高脂饲料喂养造成糖尿病肥胖小鼠模型。对照组为同龄C57小鼠

成模的KK-Ay小鼠分为模型组、吡格咧酮组、降糖消脂片高、中、低剂量组（10

2.5 g.kg-1）（11只/组）

连续灌胃给药（ig）8周。每周称体重及摄食量

隔周测血糖。药后8周取胰腺作病理切片

并取胰腺组织检测胰岛素受体及底物表达。结果:降糖消脂片各剂量组明显减轻糖尿病肥胖小鼠体重

降低血糖。病理结果显示:降糖消脂片可减少变性及凋亡的胰岛细胞。糖尿病肥胖模型组小鼠胰腺组织胰岛素受体β（insulin receptorβ

InsRβ）和胰岛素受体底物-1（insulin receptor substrate 1

IRS-1）的表达低于对照组。降糖消脂片可有效诱导InsRβ和IRS-1表达。结论:降糖消脂片对KK-Ay糖尿病肥胖小鼠有明显的治疗作用

并可诱导胰岛素受体及底物表达。

Abstract

Objective:To observe effects of Jiangtang Xiaozhi（JTXZ） tablets on expression of insulin receptor β（InsRβ） and insulin receptor substrate-1（IRS-1） in KK-Ay transgenic mice model of diabetes mellitus（DM）.Method: KK-Ay transgenic mice were used and fed with high-fat diet to induce hyperglycemia as a model of DM obesity.The C57mice with same age of KK-Ay transgenic mice were used as a control group.Thereafter

Fifty-five mice with DM obesity were divided into 5 groups（n=11） including model group without any treatment

pioglitazone hydrochloride tablets treatment group as a positive control group

and JTXZ tablets groups at high

middle and low treatment doses

and were continuously given JTXZ tablets by intragastric administration for 8 weeks.All mice were sacrificed after treatment of 8 weeks.The pathology examination of abdominal salivary gland was performed.The expression of InRβ and IRS-1 were deteced

respectively.Result:In the JTXZ tablets treatment group

compared with that in KK-Ay transgenic mice model with DM obesity

the pancreatic pathological changes were ameliorated significantly.Expression of InRβ and IRS-1 were increased in each treatment group by JTXZ tablets

respectively.Conclusion: JTXZ tablets have obvious effects of increasing levels of InRβ and IRS-1 in KK-Ay transgenic mice model with DM obesity.

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Related Author

LIU Jian-xun

REN Ye

LI Hong-kun

DONG Xiao-xia

YANG Bing

GUO Yu-jie

JIN Long

GE Zheng-yan

Related Institution

Dongzhimen Hospital， Beijing University of Chinese Medicine

Science and Technology Office， Beijing University of Chinese Medicine

Disciplinary Innovation Base of the Ministry of Education

School of Life Sciences，Beijing University of Chinese Medicine

School of Traditional Chinese Medicine （TCM）， Beijing University of Chinese Medicine

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Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-Ay Transgenic Mice Model of Diabetes Mellitus

DOI：10.13422/j.cnki.syfjx.2013.03.089

摘要

Abstract

关键词

Keywords

references

Effect of Jiangtang Xiaozhi Tablets on Expression of Insulin Receptor β and Insulin Receptor Substrate-1 in KK-A^y Transgenic Mice Model of Diabetes Mellitus