Hypotensive Effect of Jiangya Prescription of Zhuang National Herbs on Spontaneous Hypertensive Rats

TAN Zhen-yuan1; LUO Yuan2; LOU Yan1; LIANG Jian-qin3; JIANG Li-he4

doi:10.13422/j.cnki.syfjx.2013.05.014

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Hypotensive Effect of Jiangya Prescription of Zhuang National Herbs on Spontaneous Hypertensive Rats

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- Hypotensive Effect of Jiangya Prescription of Zhuang National Herbs on Spontaneous Hypertensive Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 262-265(2013)
- 作者机构：
  
  1. 广西医科大学药学院
  2. 广西中医药大学附属瑞康医院
  3. 广西中医药大学
  4. 广西大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.014
  CLC： R29
- Published：2013
- 稿件说明：
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[1]谭珍媛,罗远,罗艳,梁健钦,蒋利和.壮药降压方对自发性高血压大鼠降压作用研究[J].中国实验方剂学杂志,2013,19(05):262-265.

TAN Zhen-yuan1, LUO Yuan2, LOU Yan1, et al. Hypotensive Effect of Jiangya Prescription of Zhuang National Herbs on Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 262-265.
[1]谭珍媛,罗远,罗艳,梁健钦,蒋利和.壮药降压方对自发性高血压大鼠降压作用研究[J].中国实验方剂学杂志,2013,19(05):262-265. DOI： 10.13422/j.cnki.syfjx.2013.05.014.

TAN Zhen-yuan1, LUO Yuan2, LOU Yan1, et al. Hypotensive Effect of Jiangya Prescription of Zhuang National Herbs on Spontaneous Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 262-265. DOI： 10.13422/j.cnki.syfjx.2013.05.014.

摘要

目的:探讨壮药降压方对自发性高血压大鼠（SHR）的降压作用。方法:SHR大鼠随机分为模型组、降压方提取物高剂量组（2.0 g.kg-1）、中剂量组（1.0 g.kg-1）、低剂量组（0.5 g.kg-1）

卡托普利组（10 mg.kg-1）

每组8只。8只同龄雄性Wistar-Kyoto（WKY）大鼠为空白对照组。每周测量大鼠尾动脉压

给药6周后处死大鼠

测定血清中一氧化氮（NO）、内皮素（ET）、血管紧张素（AngⅡ）的含量。结果:降压方提取物明显降低SHR大鼠的血压

同时能显著增加大鼠血清NO含量

降低大鼠血清中ET

Ang II的含量

与模型组比较

均有显著性差异（P<0.05

P<0.01）。结论:壮药降压方提取物可能通过下调血清中ET含量和上调NO含量来发挥降压作用。

Abstract

Objective:To investigate the hypotensive effects of Jiangya Prescription

a Zhuang folk herbal medicine

on spontaneous hypertensive rats（SHR）.Method: Forty SHRs were randomly divided into five groups

untreated control

the high（2.0 g·kg-1）

middle（1.0 g·kg-1）

low（0.5 g·kg-1）-dosage groups of extract from Jiangya Prescription and captopril group（10 mg·kg-1）

with 8 rats in each group.Wistar-Kyoto rats were used as the blank group.Tail blood pressure was measured every week.Rats were sacrificed to determine serum nitric oxide（NO）

endothelin（ET）

angiotensinogen Ⅱ（AngⅡ） after six weeks of treatment.Result: The extract of Jiangya Prescription could significantly lower blood pressure

meanwhile significantly increase NO content

decrease markedly the content of ET and AngⅡ.There were significant differences with untreated control group（P<0.05

P<0.01）.Conclusion: The extract from Jiangya Prescription had a significantly hypotensive effect to SHR.Its mechanism may be related to up-regulation of NO and down-regulation of ET and Ang II.

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