Prevention and Tneatment Effect of Shenjing Fuzheng Prescription for Bone Marrow Suppression Induced by Radiotherapy in Patients with Esophageal Cancer

YANG Hui-bin; FAN Li-xia; CUI Gui-min; LIU Miao-ling; SHI Hong-yun; GAI Xiao-hui

doi:10.13422/j.cnki.syfjx.2013.05.025

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Prevention and Tneatment Effect of Shenjing Fuzheng Prescription for Bone Marrow Suppression Induced by Radiotherapy in Patients with Esophageal Cancer

更新时间：2024-09-23

- Prevention and Tneatment Effect of Shenjing Fuzheng Prescription for Bone Marrow Suppression Induced by Radiotherapy in Patients with Esophageal Cancer
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 330-332(2013)
- 作者机构：
  
  河北省保定市河北大学附属医院
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.025
  CLC： R273;R735.1
- Published：2013
- 稿件说明：
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[1]杨会彬,范丽霞,崔桂敏,刘妙玲,史鸿云,盖晓惠.参精扶正方防治食管癌放疗所致骨髓抑制的临床疗效[J].中国实验方剂学杂志,2013,19(05):330-332.

YANG Hui-bin, FAN Li-xia, CUI Gui-min, et al. Prevention and Tneatment Effect of Shenjing Fuzheng Prescription for Bone Marrow Suppression Induced by Radiotherapy in Patients with Esophageal Cancer[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 330-332.
[1]杨会彬,范丽霞,崔桂敏,刘妙玲,史鸿云,盖晓惠.参精扶正方防治食管癌放疗所致骨髓抑制的临床疗效[J].中国实验方剂学杂志,2013,19(05):330-332. DOI： 10.13422/j.cnki.syfjx.2013.05.025.

YANG Hui-bin, FAN Li-xia, CUI Gui-min, et al. Prevention and Tneatment Effect of Shenjing Fuzheng Prescription for Bone Marrow Suppression Induced by Radiotherapy in Patients with Esophageal Cancer[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 330-332. DOI： 10.13422/j.cnki.syfjx.2013.05.025.

摘要

目的:探讨参精扶正方防治食管癌放疗所致骨髓抑制的临床疗效。方法:将70例行单纯放疗的食管癌患者随机分成观察组和对照组各35例

对照组放疗起始口服利血生

20 mg/次

3次/d。观察组口服参精扶正方

1剂/d。两组疗程均到放疗结束。观察骨髓抑制情况及生活质量。结果:治疗后14

42 d观察组外周血白细胞WBC计数均高于对照组（P<0.01）;观察组出现Ⅲ度骨髓抑制例数少于对照组（P<0.05）

出现时间晚于对照组（P<0.01）;治疗后观察组血红蛋白、血小板和粒细胞水平均高于对照组（P<0.01）;观察组临床症状积分低于对照组（P<0.01）;观察组Karnofsky评分高于对照组（P<0.05）;观察组欣粒生用量少于对照组（P<0.01）。结论:参精扶正方能防治食管癌放疗所致骨髓抑制

减轻临床副反应

提高患者生活质量。

Abstract

Objective:To investigate the prevention and treatment effect of pre-treatment of Shenjing Fuzheng prescription（SFP） for bone marrow suppression induced by radiotherapy in patients with esophageal cancer.Method: Seventy patients suffered from esophageal cancer with routine radiotherapy were randomized into observation group and control group（n=35 each）.The controls were orally given leucogen 20 mg tid daily parallel to radiotherapy.The patients in the observation group were given SFP daily parallel to radiotherapy.The interventions in the two-group were lasted until the end of radiotherapy.Bone marrow suppression and quality of life were evaluated.Result: WBC count levels in the observation group on 14

42 d were higher than those in control group（P<0.01）.The cases of III degree bone marrow suppression in the observation group appeared less than that in the control group（P<0.05）

and with delayed duration of emerging（P<0.01）.In the observation group

hemoglobin

platelet count and granulocyte count were higher than those in the controls（P<0.01）;clinical symptoms scores were lower than that in the controls（P<0.01）;and Karnofsky score higher than that in the controls（P<0.05）.In the observation group

the consume of recombinant human granulocyte colony stimulating factor was less than that in the controls（P<0.01）.Conclusion: SFP can be used for prevention and treatment of bone marrow suppression caused by radiotherapy in esophageal cancer

and reduce the clinical side effects

improve patients′ quality of life.

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