Investigation of in vitro Transdermal Permeation Effect of Wantong Jingu Sprays

GE Ke-ya1; DU Mao-bo2; LIU Shu-zhi2; LI Man-ling2; KANG Chen2; SONG Li-hua1; WANG Hong-zhen3; LI Ying3

doi:10.13422/j.cnki.syfjx.2013.05.031

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Investigation of in vitro Transdermal Permeation Effect of Wantong Jingu Sprays

更新时间：2024-09-23

- Investigation of in vitro Transdermal Permeation Effect of Wantong Jingu Sprays
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 1-3(2013)
- 作者机构：
  
  1. 首都医科大学中医药学院
  2. 中国中医科学院中药研究所
  3. 通化万通药业股份有限公司
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.031
  CLC： R286.0
- Published：2013
- 稿件说明：
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[1]葛克亚,杜茂波,刘淑芝,李曼玲,康琛,宋立华,王洪珍,李颖.万通筋骨喷雾剂的体外经皮渗透效果考察[J].中国实验方剂学杂志,2013,19(05):1-3.

GE Ke-ya1, DU Mao-bo2, LIU Shu-zhi2, et al. Investigation of in vitro Transdermal Permeation Effect of Wantong Jingu Sprays[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 1-3.
[1]葛克亚,杜茂波,刘淑芝,李曼玲,康琛,宋立华,王洪珍,李颖.万通筋骨喷雾剂的体外经皮渗透效果考察[J].中国实验方剂学杂志,2013,19(05):1-3. DOI： 10.13422/j.cnki.syfjx.2013.05.031.

GE Ke-ya1, DU Mao-bo2, LIU Shu-zhi2, et al. Investigation of in vitro Transdermal Permeation Effect of Wantong Jingu Sprays[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 1-3. DOI： 10.13422/j.cnki.syfjx.2013.05.031.

摘要

目的:考察万通筋骨喷雾剂的经皮渗透效果。方法:以绿原酸为指标

采用垂直式改良Franz扩散池装置进行试验

HPLC测定含量。结果:万通筋骨喷雾剂样品的透皮速率27.919μg.cm-2.h-1

6 h内平均累积透过率13.53%;绿原酸喷雾剂的透皮速率6.636μg.cm-2.h-1

6 h内平均累积透过率3.78%。结论:万通筋骨喷雾剂的体外透皮行为符合零级方程

其经皮渗透效果优于绿原酸喷雾剂。

Abstract

Objective:To investigate transdermal permeation effect of Wantong Jingu sprays.Method:Modified Franz diffusion cell was applied to investigate in vitro transdermal absorption behavior of Wantong Jingu sprays

with the content of chlorogenic acid as index

which was determined by HPLC.Result:In six hours

accumulated transdermal rate of Wantong Jingu sprays and chlorogenic acid sprays were 13.53%

3.78%

respectively;Transdermal rate were 27.919

6.636 μg·cm-2·h-1

respectively.Conclusion:In vitro transdermal absorption behavior of Wantong Jingu sprays was in accordence with zero-level equation

its transdermal absorption effect was better than chlorogenic acid sprays.

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Related Author

GE Ke-ya

DU Mao-bo

LIU Shu-zhi

LI Man-ling

KANG Chen

SONG Li-hua

WANG Hong-zhen

Li Ying

Related Institution

Nanjing Medical University

Yancheng Health Vocational Technical College

Yancheng Institute for Drug Control of Jiangsu Province

College Pharmacy of Xinjiang Medical University

Faculty of Pharmacy,Guangxi Traditional Chinese Medical University

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