Optimization of Extraction Technology for Sulfur Dioxide from Dioscorea opposita by Plackett-Burman Design and Central Composite Design-response Surface Methodology

PENG Yue1; YIN Ling1; LI Xue-lian1; CHEN Hong-ping1; LIU Rong1; LIU You-ping1

doi:10.13422/j.cnki.syfjx.2013.05.038

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Optimization of Extraction Technology for Sulfur Dioxide from Dioscorea opposita by Plackett-Burman Design and Central Composite Design-response Surface Methodology

更新时间：2024-09-23

- Optimization of Extraction Technology for Sulfur Dioxide from Dioscorea opposita by Plackett-Burman Design and Central Composite Design-response Surface Methodology
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 32-35(2013)
- 作者机构：
  
  1. 成都中医药大学药学院
  2. 成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.038
  CLC： R283
- Published：2013
- 稿件说明：
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[1]彭月,银玲,李雪莲,陈鸿平,刘荣,刘友平.Plackett-Burman设计联用星点设计-效应面法优化山药中二氧化硫残留量测定前处理工艺[J].中国实验方剂学杂志,2013,19(05):32-35.

PENG Yue1, YIN Ling1, LI Xue-lian1, et al. Optimization of Extraction Technology for Sulfur Dioxide from Dioscorea opposita by Plackett-Burman Design and Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 32-35.
[1]彭月,银玲,李雪莲,陈鸿平,刘荣,刘友平.Plackett-Burman设计联用星点设计-效应面法优化山药中二氧化硫残留量测定前处理工艺[J].中国实验方剂学杂志,2013,19(05):32-35. DOI： 10.13422/j.cnki.syfjx.2013.05.038.

PENG Yue1, YIN Ling1, LI Xue-lian1, et al. Optimization of Extraction Technology for Sulfur Dioxide from Dioscorea opposita by Plackett-Burman Design and Central Composite Design-response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 32-35. DOI： 10.13422/j.cnki.syfjx.2013.05.038.

摘要

目的:运用Plackett-Burman试验设计和星点设计-效应面法优选山药中二氧化硫残留量测定前处理的最佳工艺。方法:以二氧化硫提取量为指标

采用单因素试验考察提取方法、溶剂用量、振荡速度、提取温度、提取时间及NaOH溶液质量分数对二氧化硫残留量测定前处理工艺的影响。运用Plackett-Burman试验设计筛选影响显著的因素

以NaOH溶液质量分数和溶剂用量为自变量

二氧化硫提取量为因变量

对自变量各水平进行多元线性回归和二项式拟合

通过效应面法选择工艺条件

并进行预测分析。结果:最佳前处理工艺为NaOH溶液质量分数0.7%

料液比1∶50.99

提取率实测值与预测值偏差3.23%。结论:优选的前处理工艺简便、预测性良好

为中药材中二氧化硫残留量测定时样品的前处理提供参考。

Abstract

Objective:To optimize extraction technology of sulfur dioxide from Dioscorea opposita by Plackett-Burman design and central composite design-response surface methodology.Method:With yield of sulfur dioxide as index

effect of extraction method

solvent amount

extraction temperature

extraction time and the mass fraction of NaOH solution on extraction technology of sulfur dioxide was investigated by single-factor test.Significant influencing factors were screened by Plackett-Burman design

independent variables were the concentration of NaOH and solvent amount

dependent variable was yield of sulfur dioxide

each level of independent variables was handled with multiple linear regression and binomial fitting

response surface methodology was used to optimize extraction process

and prediction was carried out through comparing the observed and predicted value.Result:Optimal extraction technology conditions were as followings:the mass fraction of NaOH 0.7%

solid-liquid ratio 1∶ 50.99

Bias of the observed value and the predicted value 3.23%.Conclusion:Optimized extraction technology was simple with good predictability

it could provide reference for sample pretreatment in determination of sulfur dioxide residues of traditional Chinese medicine.

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Related Author

PENG Yue

YIN Ling

LI Xue-lian

CHEN Hong-ping

LIU Rong

LIU You-ping

YU Yang

ZHOU Li-ling

Related Institution

School of Pharmacy,Chengdu University of Traditional Chinese Medicine, State Key Laboratory Breeding Base of Systematic Research,Development and Utilization of Chinese Medicine Resources

Research Institute of Traditional Chinese Medicine,Heilongjiang University of Traditional Chinese Medicine

Life Science and Technology College,Heilongjiang Bayi Agricultural University

College of Pharmacy,Shenyang Pharmaceutical University

College of Pharmacy,Heilongjiang University of Chinese Medicine

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