SHEN Lou1, YU Chu-qin1, ZHANG Kun-shui2, et al. Optimization of Dry Granulation Technology for Houyin’an Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 46-48.
SHEN Lou1, YU Chu-qin1, ZHANG Kun-shui2, et al. Optimization of Dry Granulation Technology for Houyin’an Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 46-48. DOI: 10.13422/j.cnki.syfjx.2013.05.042.
Optimization of Dry Granulation Technology for Houyin’an Tablets
摘要
目的:优选喉喑安片的干法制粒工艺。方法:采用L9(34)正交设计试验
选取轮轧压力、压轮转速、进料转速为考察因素
以多指标综合评分考察干法制粒的工艺条件;在25℃
90%RH条件下
考察制备的喉喑安片的引湿性。结果:最佳干法制粒工艺为A1B3C3
即轮轧压力4 MPa
压轮转速30 r.min-1
进料转速20 r.min-1
第10 d的引湿试验平均增重1.5%。结论:该制备工艺质量稳定
产品防潮性良好。
Abstract
Objective:To optimize dry granulation technology of Houyin’an tablets.Method:With wheel rolling pressure
wheel speed and feeding speed as investigation factors
L9(34) orthogonal test was used to optimize dry granulation technology conditions with muiti-index composite score as index;Under 25 ℃
90%RH conditions
hygroscopicity of prepared Houyin’an tablets was investigated.Result:Optimum dry granulation technology was A1B3C3
that was the wheel rolling pressure of 4 MPa
pressure wheel speed 30 r·min-1
feeding speed of 20 r·min-1.On the tenth day
average increased weight of Houyin’an tablets was 1.5% by hygroscopicity test.Conclusion:Quality of Houyin’an tablets was stable with good moisture resistance
Optimization of Dry Granulation Technology for Houyin'an Tablets
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Research Progress of Granulation Technology for Taste Masking of Pharmaceutical Preparation
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Study on Extract Technology of Alcohol in Danpu Keli with Orthogonal Design
Related Author
SHEN Lou
YU Chu-qin
ZHANG Kun-shui
HUANG Si-yu
Zan-yang HUANG
Ya-jing WANG
Dong-li QI
Di GAO
Related Institution
Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education,Tianjin University of Traditional Chinese Medicine
Jiangxi University of Traditional Chinese Medicine
Shuguang Hospital Affiliated Shanghai University of Traditional Chinese Medicine
Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine, Key Laboratory of Scientific Preparation for Clinical Effective Prescription of State Administration of Traditional Chinese Medicine
Drug Research Center for Nephropathy,Guangzhou Consun Pharmaceutical Co.Ltd