Atmospheric Pressure Chemistry Ionization Mass Spectrum Analysis of Gingkolides in Ginkgo biloba Extract

GONG Li-li; KONG De-gang; SUN Guo-ming; JIANG Hai-qiang; RONG Rong; TIAN Jing-zhen

doi:10.13422/j.cnki.syfjx.2013.05.067

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Atmospheric Pressure Chemistry Ionization Mass Spectrum Analysis of Gingkolides in Ginkgo biloba Extract

更新时间：2024-09-23

- Atmospheric Pressure Chemistry Ionization Mass Spectrum Analysis of Gingkolides in Ginkgo biloba Extract
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 155-158(2013)
- 作者机构：
  
  山东中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.067
  CLC： R284
- Published：2013
- 稿件说明：
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[1]巩丽丽,孔得刚,孙国明,蒋海强,容蓉,田景振.银杏叶提取物中银杏萜内酯成分大气压化学电离质谱分析[J].中国实验方剂学杂志,2013,19(05):155-158.

GONG Li-li, KONG De-gang, SUN Guo-ming, et al. Atmospheric Pressure Chemistry Ionization Mass Spectrum Analysis of Gingkolides in Ginkgo biloba Extract[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 155-158.
[1]巩丽丽,孔得刚,孙国明,蒋海强,容蓉,田景振.银杏叶提取物中银杏萜内酯成分大气压化学电离质谱分析[J].中国实验方剂学杂志,2013,19(05):155-158. DOI： 10.13422/j.cnki.syfjx.2013.05.067.

GONG Li-li, KONG De-gang, SUN Guo-ming, et al. Atmospheric Pressure Chemistry Ionization Mass Spectrum Analysis of Gingkolides in Ginkgo biloba Extract[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 155-158. DOI： 10.13422/j.cnki.syfjx.2013.05.067.

摘要

目的:用高效液相色谱-大气压化学电离-质谱（HPLC-APCI-MS）法对银杏叶提取物中银杏内酯进行分析。方法:液相色谱条件Agilent 3000 Extend-C18色谱柱（4.6 mm×250 mm

5μm）

流动相甲醇-水30∶70

流速0.8 mL.min-1

检测波长220 nm

柱温35℃;负离子模式检测。结果:解析鉴别了白果内酯和银杏内酯A

其分子离子峰的m/z分别为324.8

407.1

422.9

438.9

422.9。结论:为银杏内酯的检测提供了一种快速有效的质谱方法。

Abstract

Objective:To study gingkolides in Ginkgo biloba extract by HPLC-APCI-MS.Method:Analysis of gingkolides was done by HPLC-APCI-MS in negative ion mode.The separation was performed on Agilent 3000 Extend-C18 column with methanol-water（30∶ 70） as mobile phase

and the flow rate was 0.8 mL· min-1.The spectrometer was APCI-MS.Result: Bibobalide

ginkgolide A

J were identified

the m/z of molecular ion peak is respectively 324.8

407.1

422.9

438.9

422.9.Conclusion:The established method by HPLC-APCI-MS can be adopted for sensitive and rapid identification of gingkolides.

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Related Author

GONG Li-li

KONG De-gang

SUN Guo-ming

JIANG Hai-qiang

RONG Rong

TIAN Jing-zhen

WANG Dan

ZHANG Jing

Related Institution

College of Pharmaceutical Science, Yunnan University of Traditional Chinese Medicine

Henan University of Chinese Medicine

Zhongjing Wanxi Pharmaceutical Co. Ltd.

Hubei Institute for Food and Drug Control

Shanxi Renyuantang Pharmaceutical Co.,Ltd.

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