Site of Analgesic Effect of Total Saponin from Thladiantha dubia Root

SONG Li-ping1; ZHAO Chun-ying2; TONG Ji-ming2

doi:10.13422/j.cnki.syfjx.2013.05.075

您当前的位置：

首页 >

文章列表页 >

Site of Analgesic Effect of Total Saponin from Thladiantha dubia Root

更新时间：2024-09-23

- Site of Analgesic Effect of Total Saponin from Thladiantha dubia Root
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 200-202(2013)
- 作者机构：
  
  1. 承德护理职业学院
  2. 河北省中药研究与开发重点实验室-承德医学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.075
  CLC： R285.5
- Published：2013
- 稿件说明：
移动端阅览
[1]宋利萍,赵春颖,佟继铭.赤雹根总皂苷镇痛作用部位研究[J].中国实验方剂学杂志,2013,19(05):200-202.

SONG Li-ping1, ZHAO Chun-ying2, TONG Ji-ming2. Site of Analgesic Effect of Total Saponin from Thladiantha dubia Root[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 200-202.
[1]宋利萍,赵春颖,佟继铭.赤雹根总皂苷镇痛作用部位研究[J].中国实验方剂学杂志,2013,19(05):200-202. DOI： 10.13422/j.cnki.syfjx.2013.05.075.

SONG Li-ping1, ZHAO Chun-ying2, TONG Ji-ming2. Site of Analgesic Effect of Total Saponin from Thladiantha dubia Root[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 200-202. DOI： 10.13422/j.cnki.syfjx.2013.05.075.

摘要

目的:探讨赤雹根总皂苷（TSRT）的镇痛作用部位。方法:昆明种小鼠120只

随机分为福尔马林致痛实验组和改进小鼠酵母致炎性组织疼痛模型实验组

每组60只。各组再分为TSRT 240

120

60 mg.kg-1组

阿司匹林200 mg.kg-1组

吗啡5 mg.kg-1组和空白对照组

每组10只

吗啡组腹腔注射给药

其余各组均灌胃给药。采用小鼠福尔马林致痛实验和改进小鼠炎性组织疼痛模型观察TSRT对痛反应的影响

分析其镇痛作用部位。结果:在福尔马林实验中

TSRT 120

60 mg.kg-1剂量组小鼠第Ⅱ时相痛反应积分显著低于NS组（P<0.01）

但对第Ⅰ时相疼痛积分无明显影响;TSRT 240 mg.kg-1剂量组小鼠第Ⅰ时相和第Ⅱ时相痛反应积分均低于NS组（P<0.05

P<0.01）。在小鼠炎性组织疼痛模型实验中

TSRT各剂量组炎性足痛阈显著高于NS组（P<0.01）

正常足痛阈与NS组比较差异无显著意义。结论:TSRT镇痛作用部位主要在外周。

Abstract

Objective:To invastigate the site of analgesic effect of the total saponin from Thladiantha dubia root（TSRT）.Method: Kunming mice 120 were devided into formalin test and improved Randall-Selitto method grougs

60 in each groug.Sixty mices were divided into TSRT 240

120

60 mg·kg-1grougs

Asp 200 mg·kg-1groug

Mor 5 mg·kg-1

grpop and NS group.The Mor group was given by sc

the others were given by ig.The site of analgesic effect of TSRT respectively was analysed by formalin test and mend Randall-Selitto method in mice.Result:In formalin test in mice

TSRT of 120

60 mg·kg-1 significantly lowered the pain score of the second phase（P<0.05 vs NS group）

but there is no effect on the pain score of the first phase（P>0.05 vs NS group）

TSRT of 240 mg·kg-1 lowered both the pain scores of the first phase and second phase（P<0.05-0.01 vs NS group）.In imoroved Randall-Selitto method in mice

TSRT markedly increased the pain threshold value on inflammation foot（P<0.01 vs NS group）

but pain threshold value in normal foot did not obviously elevated（P>0.05 vs NS group）.Conclusion: The site of analgesic effect of TSRT is mainly located in the periphery.

关键词

Keywords

references

Views

109

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Site of Analgesic Effect of Total Saponin from Root

Related Author

SONG Li-ping

ZHAO Chun-ying

TONG Ji-ming

Related Institution

No data

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰