Antioxidative Effects in vitro of Polysaccharides in Sophora alopecuroides and its Derivatives

ZHAO Yong-an1; CHEN Guan2; TAO Zun-wei2

doi:10.13422/j.cnki.syfjx.2013.05.081

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Antioxidative Effects in vitro of Polysaccharides in Sophora alopecuroides and its Derivatives

更新时间：2024-09-23

- Antioxidative Effects in vitro of Polysaccharides in Sophora alopecuroides and its Derivatives
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 229-232(2013)
- 作者机构：
  
  1. 天津医科大学
  2. 天津市医药科学研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.081
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]赵永安,陈冠,陶遵威.苦豆子多糖及其衍生物的体外抗氧化活性[J].中国实验方剂学杂志,2013,19(05):229-232.

ZHAO Yong-an1, CHEN Guan2, TAO Zun-wei2. Antioxidative Effects in vitro of Polysaccharides in Sophora alopecuroides and its Derivatives[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 229-232.
[1]赵永安,陈冠,陶遵威.苦豆子多糖及其衍生物的体外抗氧化活性[J].中国实验方剂学杂志,2013,19(05):229-232. DOI： 10.13422/j.cnki.syfjx.2013.05.081.

ZHAO Yong-an1, CHEN Guan2, TAO Zun-wei2. Antioxidative Effects in vitro of Polysaccharides in Sophora alopecuroides and its Derivatives[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 229-232. DOI： 10.13422/j.cnki.syfjx.2013.05.081.

摘要

目的:对苦豆子多糖及其衍生物的体外抗氧化活性进行了研究。方法:将苦豆子多糖硫酸化、磷酸化修饰后

以维生素C（VC）为对照

分别测定苦豆子多糖（SAP）、硫酸化苦豆子多糖（SAPS）和磷酸化苦豆子多糖（SAPP）3种多糖对二苯代苦味酰自由基（DPPH）、羟自由基（.OH）、超氧自由基（O2-.）的体外抗氧化活性及还原力。结果:SAPS和SAPP表现出不同程度抗氧化活性

并随浓度增加

活性增强

其中SAPS和SAPP清除DPPH能力（IC50分别是4.573

6.542 mg.L-1）与SAP（IC5010.233 mg.L-1）相比

有显著提高;SAPP清除羟自由基（IC504.368 mg.L-1）和SAPS清除超氧自由基（IC502.651 mg.L-1）能力显著提高。结论:硫酸化和磷酸化修饰能提高苦豆子多糖的体外抗氧化活性。

Abstract

Objective:To investigate the antioxidant effect in vitro of polysaccharides in Sophora alopecuroides（SAP） and its derivatives.Method: After sulfation and phosphorylation of the SAP

the scavenging capacities of 1

1-diphenyl-2-picrylhydrazyl

superoxide anion radicals

hydroxyl free radicals and reducing power were assayed

with vitamin C（VC） as control.Result: The activity of modification products was increased with the concentration increasing.The scavenging rate against 1

1-dipheny 1.2-picrylhydmiyl DPPH 50% inhibition concentration（IC50

4.573 mg·L-1） and superoxide anion radicals IC50 2.651 mg·L-1 of SAPS were more than SAP.The scavenging rate against DPPH IC50

6.542 mg·L-1 and hydroxyl free radicals IC50 4.368 mg·L-1 of SAPP were more than SAP.Conclusion: The antioxidant activity of polysaccharides in S.alopecuroides can be improved through sulfation and phosphorylation of the SAP.

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