Effects of Lycium barbarum Polysaccharides on Lipid Metabolism and Oxygen Free Radicals in Hyperlipidemic Rats

ZHAO Jing-li1; GAO Hong-mei2; YU Hai-shuai1

doi:10.13422/j.cnki.syfjx.2013.05.084

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Effects of Lycium barbarum Polysaccharides on Lipid Metabolism and Oxygen Free Radicals in Hyperlipidemic Rats

更新时间：2024-09-23

- Effects of Lycium barbarum Polysaccharides on Lipid Metabolism and Oxygen Free Radicals in Hyperlipidemic Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 241-243(2013)
- 作者机构：
  
  1. 吉林工业职业技术学院
  2. 长春中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2013.05.084
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]赵晶丽,高红梅,于海帅.枸杞多糖对高脂血症大鼠血脂代谢及氧自由基的影响[J].中国实验方剂学杂志,2013,19(05):241-243.

ZHAO Jing-li1, GAO Hong-mei2, YU Hai-shuai1. Effects of Lycium barbarum Polysaccharides on Lipid Metabolism and Oxygen Free Radicals in Hyperlipidemic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 241-243.
[1]赵晶丽,高红梅,于海帅.枸杞多糖对高脂血症大鼠血脂代谢及氧自由基的影响[J].中国实验方剂学杂志,2013,19(05):241-243. DOI： 10.13422/j.cnki.syfjx.2013.05.084.

ZHAO Jing-li1, GAO Hong-mei2, YU Hai-shuai1. Effects of Lycium barbarum Polysaccharides on Lipid Metabolism and Oxygen Free Radicals in Hyperlipidemic Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 241-243. DOI： 10.13422/j.cnki.syfjx.2013.05.084.

摘要

目的:探讨枸杞多糖（LBP）对高脂血症大鼠血脂代谢及氧自由基的影响。方法:健康雄性Wistar大鼠60只

按体重随机分为空白对照组、高脂血症模型组、LBP高、中、低剂量组和阳性对照组;除空白对照组

其余各组采用高脂饲料喂养法建立大鼠高脂血症模型;模型建立成功后

空白对照组和模型组ig给予蒸馏水

其余各组分别灌胃给予LBP（80

20 mg.kg-1）及辛伐他汀2 mg.kg-1。4周后

测定血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白（HDL-C）、超氧化物歧化酶（SOD）、丙二醛（MDA）及谷胱甘肽过氧化物酶（GSH-Px）水平。结果:与高脂血症模型组比较

LBP各剂量组大鼠血清TC

LDL-C均显著下降（P<0.05或P<0.01）

而HDL-C则显著升高（P<0.05）;SOD

GSH-Px活性显著升高（P<0.05或P<0.01）

而MDA水平显著下降（P<0.05或P<0.01）。结论:LBP能调节高脂血症大鼠血脂代谢水平

清除氧自由基

防止脂质过氧化

延缓动脉粥样硬化形成。

Abstract

Objective:To study the effects of Lycium barbarum polysaccharides（LBP） on lipid metabolism and oxygen free radicals in hyperlipidemic rats.Method: Sixty Wistar rats were randomly divided into six groups: normal control group

high-lipid model group

LBP high

medium and low-dose group and positive control group.The rat model of hyperlipidemic was established by high-fat diet feeding.After 4 weeks

the rats were given with LBP（80

20 mg·kg-1） and simvastatin 2 mg·kg-1.At the end of 4 weeks

the abdominal aortic blood was collected and determined total cholesterol（TC）

triglyceride（TG）

low density lipoprotein cholesterol（LDL-C）

high density lipoprotein cholesterol（HDL-C）

superoxide dismutase（SOD）

malondialdehyde（MDA） and glutathione peroxidase（GSH-Px）.Result: Compared with hyperlipidemia model group

serum TC

LDL-C level in each treatment group decreased significantly（P<0.05 or P<0.01）

HDL-C significantly increased（P<0.05）;SOD and GSH-Px activity significantly increased（P<0.05 or P<0.01）

MDA levels decreased significantly（P<0.05 or P<0.01）.Conclusion: LBP could adjust the level of lipid metabolism of rat model of hyperlipidemia

inhibit the damage from oxygen free radicals

prevent lipid peroxidation

and delay atherosclerotic formed.

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Related Institution

Chengdu University of TCM

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

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Chengdu University of Traditional Chinese Medicine（TCM）

Research Center for Differentiation and Development of Traditional Chinese Medicine （TCM） Basic Theory/Jiangxi Province Key Laboratory of Biological Etiologies of TCM/First-Level Discipline Platform of Chinese and Western Integrative Medicine/Experimental Animal and Scientific Technology Center of Jiangxi University of Chinese Medicine/School of Pharmacy， Jiangxi University of Chinese Medicine

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