YANG Yu-jie1, LIU Zhen-hong1, WANG Chun-min2, et al. Anti-inflammatory and Analgesic Effects of Jingfukang Granule by Water Extraction Coupling Rectification[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 274-278.
YANG Yu-jie1, LIU Zhen-hong1, WANG Chun-min2, et al. Anti-inflammatory and Analgesic Effects of Jingfukang Granule by Water Extraction Coupling Rectification[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 274-278. DOI: 10.13422/j.cnki.syfjx.2013.05.091.
Anti-inflammatory and Analgesic Effects of Jingfukang Granule by Water Extraction Coupling Rectification
Objective:To study the anti-inflammatory and analgesic effects of Jingfukang Granule by water extraction coupling rectification(WER).Method: The anti-inflammatory effect was evaluated by ear edema induced by dimethylbenzene
celiac capillary vessel permeability induced by acetic acid in mice and foot swelling induced by carrageenan in rats.The analgesic effect was evaluated by writhing method in mice
hot-plate method in mice and water bath method in rats.Result: Compared to Jingfukang Granule
Jingfukang Granule by WER could significantly inhibit the ear edema formation(P<0.01
P<0.001)
acetic acid-induced increase in capillary permeability and foot swelling(P<0.05
P<0.01).Jingfukang Granule by WER could also significantly increase the threshold of pain(P<0.01
P<0.001).It could also decrease the contents of interleakin(IL-1)
fumor mecrosis factor-α(TNF-α) and prostaglaodin E2(PGE2)(P<0.01
P<0.001).Conclusion: Jingfukang Granule by WER has more significant anti-inflammatory and analgesic effects
Anti-inflammatory and Analgesic Effects of Jingfukang Granule by Water Extraction Coupling Rectification
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Related Author
YANG Yu-jie
LIU Zhen-hong
WANG Chun-min
GONG Rong-hui
Hao WU
Xiao-yin WEN
Peng YAN
Shui-rong SHEN
Related Institution
National Clinical Research Center for Respiratory Disease,State Key Laboratory of Respiratory Disease,Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University
Guangdong Institute of Nanshan Pharmaceutical Innovation
Duke Global Health Institute, Duke Medical Center,Duke University,North Carolina
Cangzhou Medical College
Department of New drug R&D in Guangzhou University of Traditional Chinese Medicine