Optimization of Extraction Technology of Total Flavonoids from Poplar Buds Based on Central Composite Design-Response Surface Methodology and Orthogonal Design

LIU Chang-long; LI Hai-tao

doi:10.13422/j.cnki.syfjx.2014100026

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Optimization of Extraction Technology of Total Flavonoids from Poplar Buds Based on Central Composite Design-Response Surface Methodology and Orthogonal Design

更新时间：2024-01-04

- Optimization of Extraction Technology of Total Flavonoids from Poplar Buds Based on Central Composite Design-Response Surface Methodology and Orthogonal Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 10, Pages: 26-28(2014)
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- DOI：10.13422/j.cnki.syfjx.2014100026
  CLC： TQ461
- Published：2014
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LIU Chang-long, LI Hai-tao. Optimization of Extraction Technology of Total Flavonoids from Poplar Buds Based on Central Composite Design-Response Surface Methodology and Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 26-28.
DOI：

LIU Chang-long, LI Hai-tao. Optimization of Extraction Technology of Total Flavonoids from Poplar Buds Based on Central Composite Design-Response Surface Methodology and Orthogonal Design[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 26-28. DOI： 10.13422/j.cnki.syfjx.2014100026.

摘要

目的：优选杨树芽总黄酮的提取工艺。方法：以总黄酮含量为指标，在单因素试验基础上，采用正交试验联合星点设计-效应面法考察乙醇体积分数、提取时间和料液比对杨树芽总黄酮提取工艺的影响。结果：正交试验确定最佳提取工艺为加13倍量90%乙醇超声提取2次，每次24 min；总黄酮质量分数达28.82%。星点设计-效应面法确定最佳提取工艺为加14倍量80%乙醇超声提取2次，每次24 min；总黄酮质量分数达31.14%。结论：星点设计-效应面法较正交设计法更为准确，2种方法结合应用可使中药提取工艺优化具有良好预测性。

Abstract

Objective: To optimize extraction process of total flavonoids from poplar buds. Method: With the content of total flavonoids from poplar buds as index

based on single factor tests

orthogonal test was adopted to optimize extraction technology by taking ethanol concentration

extraction time and solid-liquid ratio as factors. Result: Optimum process determined by orthogonal test was as following:extracted tiwce with 13 times the amount of 90% ethanol for 30 min per time;The content of total flavonoids was 28.82%.The best process optimized by central composite design-response surface methodology was as following:extracted twice with 14 times the amount of 80% ethanol for 24 min per time;The content of total flavonoids was 31.14%. Conclusion: Central composite design-response surface methodology was better than orthogonal method in accuracy

combined two methods for optimizing application of extraction process for traditional Chinese medicine had good predictability.

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