Effect of Qili Qiangxin Capsule on AQP-2 and Heart Function in Experimentally Induced Heart Failure

ZHANG Jian; CUI Xiang-ning; CAO Jian

doi:10.13422/j.cnki.syfjx.2014100183

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Effect of Qili Qiangxin Capsule on AQP-2 and Heart Function in Experimentally Induced Heart Failure

更新时间：2024-01-04

- Effect of Qili Qiangxin Capsule on AQP-2 and Heart Function in Experimentally Induced Heart Failure
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 10, Pages: 183-187(2014)
- 作者机构：
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- DOI：10.13422/j.cnki.syfjx.2014100183
  CLC： R285.5
- Published：2014
- 稿件说明：
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ZHANG Jian, CUI Xiang-ning, CAO Jian. Effect of Qili Qiangxin Capsule on AQP-2 and Heart Function in Experimentally Induced Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 183-187.
DOI：

ZHANG Jian, CUI Xiang-ning, CAO Jian. Effect of Qili Qiangxin Capsule on AQP-2 and Heart Function in Experimentally Induced Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 183-187. DOI： 10.13422/j.cnki.syfjx.2014100183.

摘要

目的：探讨芪苈强心胶囊对改善慢性心衰（CHF）大鼠的心功能及水通道蛋白-2 （AQP-2）表达的影响及其改善慢性心力衰竭水代谢紊乱的机制。方法：结扎冠脉左前降支，建立急性心肌梗死（AMI）模型，存活者随机分为模型组（等体积水），芪苈强心组（1 g·kg-1·d-1），缬沙坦组（10 mg·kg-1·d-1），另设假手术组（等体积水）。给药4周后，应用超声心动图检测大鼠的心功能；并通过免疫组化和Western blotting检测大鼠肾集合管AQP-2表达。结果：与假手术组相比，模型组左心室舒张末期内径（LVEDD）和左心室舒张末期内径（LVESD）明显增加，射血分数（EF）和短轴缩短分数（FS）显著降低（P<0.05），证实造模成功；与模型组相比，芪苈强心组和缬沙坦组LVEDD和LVESD均明显减小，EF和FS均显著升高（P<0.05）；芪苈强心组与缬沙坦组比较，差异无统计学意义；与假手术组相比，模型组AQP-2表达水平显著升高（P<0.05）；与模型组相比，芪苈强心和缬沙坦组AQP-2表达均显著降低（P<0.05），两组AQP-2表达比较，差异亦无统计学意义。结论：芪苈强心可有效下调AQP-2的表达水平，调节由慢性心衰导致的水代谢紊乱，改善水肿症状、从而提高慢性心衰患者的生存质量。

Abstract

Objective: To study Qili Qiangxin capsule(QL)' s function in improves the chronic heart failure rats' cardiac function and its' influence in the aquaporin-2 Water channel expression

then discuss benefit of how Qili Qiangxin therapies for disorders that chronic heart failure rats' aberrant water movement. Method: The proximal left anterior descending branch (LAD) of coronary artery was ligated using a terylene suture in acute myocardial infarction(AMI) rats

after building AMI model successfully

survivors were randomly divided into four groups

model group (equal volume of water)

QL group (1 g·kg-1·d-1)

valsartan group (10 mg-1·kg-1·d-1)

sham-operated group (equal volume of water) .Drug intervention four weeks

then detection of related indicators. Echocardiography and the expressions of aquaporin-2 were detected by the method of immunohistochemistry and western blotting were assessed 4 weeks after the drug therapy. Result: Compared with the sham-operated group

the left ventricular end-diastolic dimension(LVEDD) and left ventricular end-systolic dimension(LVESD) of model group is significantly increased

ejection fractions(EF) and factional shortening(FS) was significantly lower (P<0.05); compared with model group

QL group LVEDD and LVESD is significantly reduced

EF and FS were significantly higher (P<0.05). There was no significant difference between QL group and valsartan group; compared with the sham-operated group

the aquaporin-2 water channel expression levels were significantly higher in model group(P<0.05); compared with the model group

the AQP-2 expression were reduced to varying degrees in QL and valsartan group (P<0.05); while there was no significant difference between QL group and valsartan group. Conclusion: QL can be effectively reduced AQP-2 expression levels

improve chronic heart failure caused by the water metabolism

elimination of edema symptoms

thereby improving the quality of life in patients with chronic heart failure.

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