Clinical Research of Huangkui Capsule in Treating Chronic Kidney Disease Ⅲ Phase of Chronic Nephritis in 37 Cases

SHEN Ye-qu; LIAO Shun-hua; SUN Yue; JIANG Yu-feng; HE Li-qun

doi:10.13422/j.cnki.syfjx.2014100205

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Clinical Research of Huangkui Capsule in Treating Chronic Kidney Disease Ⅲ Phase of Chronic Nephritis in 37 Cases

更新时间：2024-01-04

- Clinical Research of Huangkui Capsule in Treating Chronic Kidney Disease Ⅲ Phase of Chronic Nephritis in 37 Cases
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 10, Pages: 205-208(2014)
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- DOI：10.13422/j.cnki.syfjx.2014100205
  CLC： R692.3
- Published：2014
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SHEN Ye-qu, LIAO Shun-hua, SUN Yue, et al. Clinical Research of Huangkui Capsule in Treating Chronic Kidney Disease Ⅲ Phase of Chronic Nephritis in 37 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 205-208.
DOI：

SHEN Ye-qu, LIAO Shun-hua, SUN Yue, et al. Clinical Research of Huangkui Capsule in Treating Chronic Kidney Disease Ⅲ Phase of Chronic Nephritis in 37 Cases[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(10): 205-208. DOI： 10.13422/j.cnki.syfjx.2014100205.

摘要

目的：探讨黄葵胶囊对湿热型慢性肾炎慢性肾脏病（CKD）Ⅲ期患者的临床疗效。方法：按就诊顺序随机分为两组，最终纳入统计的治疗组37例，对照组36例，对照组针对危险因素等进行一般治疗与营养治疗，治疗组在对照组治疗的基础上加用黄葵胶囊（2.5 g/次，3 次/d，饭后30 min口服）治疗，检测治疗前后24 h尿蛋白定量、血肌酐（SCr）、血尿素氮（BUN）、肾小球滤过率（GFR）。结果：黄葵胶囊治疗组能明显改善慢性肾炎CKD3期湿热型患者的临床症状（P<0.05），降低SCr，24 h尿蛋白定量（P<0.05），使GFR有显著的增加（P<0.01），两组治疗后比较统计学有显著性差异。结论：黄葵胶囊能减少蛋白尿，改善肾功能，尤其能明显升高GFR，具有稳定GFR作用。

Abstract

Objective: To investigate the curative effects of Huangkui capsule on dampness-heat of chronic kidney disease (CKD) 3 phase. Method: The patients were randomly divided into conventional western medicine treated group (control group

36 cases) and conventional western medicine plus Huangkui capsule treated group (treatment group

37 cases).The serum-creatinine (SCr)

blood urea nitrogen (BUN)

proteinuria (Pro) and glomerular filtration rate (GFR)were examined in 37 cases

compared with conventional medicine treated group with western medicine. Result: Combined treatment of Chinese and western medicine can improve symptoms and decrease SCr

proteinuria

and increase the level of GFR in the patients with dampness-heat of CKD 3 period patients. Conclusion: Huangkui capsule combined with conventional western medicine can reduce proteinuria and improve renal function

can effectively increased significantly the GFR in the patients with CKD 3 period of chronic nephritis.

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