Objective: The aim of this study is to observe the curative effect of Jiawei Buyang Huanwu decoction in treating degenerative spondylolisthesis. And to compare whether it is superior to the traditional treatment method combined with manipulation in improving the lumbosacral angle or enhancing the stability of lumbar spine. Method: One hundred and forty-two cases of degenerative lumbar spondylolisthesis patients were randomly divided into experimental group of 68 cases and 74 cases in the control group

experimental group was treated with Jiawei Buyang Huanwu decoction combined with manipulation

while the control group was given celecoxib capsules 200 mg 1 times a day orally combined with manipulation

2 weeks for 1 courses. Before treatment and after 1 courses of treatment

the patients' symptoms were scored by JOA and the lumbosacral angle was measured by Ferguson method. The rate of improvement was calculated according to the changes in the score and lumbosacral angle before and after treatment. Result: The total effective rate of experimental group was 95.59%

while the rate of the control group was 90.54%

there was significant difference between the two groups (P<0.05). Lumbosacral angle in the experimental group before treatment was (46.45±1.21)°

after treatment

the lumbosacral angle was (41.24±1.14)°.However

in the control group

lumbosacral angle was (46.29±1.18)° before treatment and (43.17±1.01)° after treatment. There was significant difference between two groups (P<0.05). Conclusion: Jiawei Buyang Huanwu decoction has good curative effect in treating degenerative lumbar spondylolisthesis

and it is superior to the traditional treatment method combined with manipulation in improving the lumbosacral angle and enhancing the stability of lumbar spine.It is a safe and effective treatment with less adverse reactions in treating the degenerative lumbar spondylolisthesis.