Contents Change of Alkaloids in Coptidis Rhizoma by Different Proportions of Compatibility with Ginseng Radix et Rhizoma

CHEN A-li; YANG Yong-xia; WANG Shu-mei; LIANG Sheng-wang

doi:10.13422/j.cnki.syfjx.2014110013

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Contents Change of Alkaloids in Coptidis Rhizoma by Different Proportions of Compatibility with Ginseng Radix et Rhizoma

更新时间：2024-01-04

- Contents Change of Alkaloids in Coptidis Rhizoma by Different Proportions of Compatibility with Ginseng Radix et Rhizoma
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 11, Pages: 13-15(2014)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014110013
  CLC： R283.6;R284.1
- Published：2014
- 稿件说明：
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CHEN A-li, YANG Yong-xia, WANG Shu-mei, et al. Contents Change of Alkaloids in Coptidis Rhizoma by Different Proportions of Compatibility with Ginseng Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 13-15.
DOI：

CHEN A-li, YANG Yong-xia, WANG Shu-mei, et al. Contents Change of Alkaloids in Coptidis Rhizoma by Different Proportions of Compatibility with Ginseng Radix et Rhizoma[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 13-15. DOI： 10.13422/j.cnki.syfjx.2014110013.

摘要

目的：探讨黄连与人参不同配伍剂量对水煎液中盐酸小檗碱、盐酸药根碱含量的影响。方法：人参黄连分别按1：0，2：1，1.5：1，0.5：1比例配伍，煎煮制备水煎液，采用HPLC测定不同配伍剂量水煎液中黄连生物碱的含量。结果：人参-黄连不同配伍样品中盐酸小檗碱质量分数分别为36.68，39.41，44.33 mg·g-1，盐酸药根碱分别为8.607，8.349，10.790 mg·g-1，二者含量随人参用量的减少而增加。结论：黄连-人参配伍后不利于盐酸小檗碱和盐酸药根碱的溶出，按0.5：1配伍时黄连中2种生物碱含量均最高。

Abstract

Objective:To investigate contents change of jatrorrhizine hydrochloride and berberine hydrochloride in decoction by different proportions of compatibility of Coptidis Rhizoma and Ginseng Radix et Rhizoma. Method:Coptidis Rhizoma and Ginseng Radix et Rhizoma were made up a prescription by proportions of 2:1

1.5:1

0.5:1

respectively;HPLC was adopted to determine contents of alkaloids in decoction. Result:The content of berberine hydrochloride were 36.68

39.41

44.33 mg·g-1 in different proportions of compatibility of Coptidis Rhizoma and Ginseng Radix et Rhizoma

while the content of jatrorrhizine hydrochloride were 8.607

8.349

10.790 mg·g-1

these two components increased with decreasing dosage of Ginseng Radix et Rhizoma. Conclusion:Compatibility of Coptidis Rhizoma and Ginseng Radix et Rhizoma was not beneficial to dissolution of berberine hydrochloride and jatrorrhizine hydrochloride

compatibility of 0.5:1 was most beneficial to dissolution of these two ingredients.

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Related Institution

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