Optimization of Extraction and Purification Processes for Shengmai Dispersible Tablets by Orthogonal Test

ZHU Zhi-jun; CHEN Yao-sheng; ZHANG Nan-nan; JIANG Ya-chao; SU Xiao-kai

doi:10.13422/j.cnki.syfjx.2014110041

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Optimization of Extraction and Purification Processes for Shengmai Dispersible Tablets by Orthogonal Test

更新时间：2024-01-04

- Optimization of Extraction and Purification Processes for Shengmai Dispersible Tablets by Orthogonal Test
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 20, Issue 11, Pages: 41-44(2014)
- 作者机构：
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- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2014110041
  CLC： R286;TQ461
- Published：2014
- 稿件说明：
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ZHU Zhi-jun, CHEN Yao-sheng, ZHANG Nan-nan, et al. Optimization of Extraction and Purification Processes for Shengmai Dispersible Tablets by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 41-44.
DOI：

ZHU Zhi-jun, CHEN Yao-sheng, ZHANG Nan-nan, et al. Optimization of Extraction and Purification Processes for Shengmai Dispersible Tablets by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2014, 20(11): 41-44. DOI： 10.13422/j.cnki.syfjx.2014110041.

摘要

目的：优选生脉分散片的提取纯化工艺。方法：以提取物中人参皂苷Rg1，Re含量及浸膏得率的综合评分为指标，采用正交试验考察乙醇体积分数、溶剂用量、提取时间对提取工艺的影响；采用壳聚糖絮凝沉降法，通过正交试验考察提取液浓缩程度、壳聚糖用量、静置时间对纯化工艺的影响。结果：最佳提取工艺为加8倍量85%乙醇回流提取3次，每次2 h；人参皂苷Rg1，Re质量分数分别为0.251%，0.074%。最佳纯化工艺为提取液生药质量浓度1 g·mL-1，壳聚糖用量10%，静置时间12 h；人参皂苷Rg1，Re质量分数分别为0.394%，0.116%。结论：优选的提取纯化工艺稳定合理，为生脉分散片的剂型改革提供参考。

Abstract

Objective:To optimize extraction and purification processes of Shengmai dispersible tablets. Method:Taking composite score of contents of ginsenoside Rg1

Re and yield of extract as index

orthogonal design was adopted to investigate effects of ethanol concentration

solid-liquid ratio

extracting time on extraction process;Chitosan flocculation sedimentation method was employed

orthogonal test was adopted to optimize purification technology with concentration degree of extracting solution

dosage of chitosan

standing time as factors. Result:The best extraction process was as follows:extracted thrice with eight times the amount of 85% ethanol for 2 h each time;contents of ginsenoside Rg1 and Re were 0.251% and 0.074%.Optimum purification process was as following:the concentration of extracting solution 1 g·mL-1

dosage of chitosan 10%

standing time for 12 h; contents of ginsenoside Rg1 and Re were 0.394% and 0.116%. Conclusion:This optimized process was stable and feasible for providing a reference to dosage-form reformation of Shengmai dispersible tablets.

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Related Institution

School of Chinese Materia Medica,Beijing University of Traditional Chinese Medicine

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